Synthesis, Crystal Structure and DNA Binding Studies of Zn(II) Complex with 1,3-Bis(benzimidazol-2-yl)-2-oxapropane

Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (8): 793-798. Previous Articles Next Articles

Original Articles

1,3-双(2-苯并咪唑基)-2-氧杂丙烷与锌配合物的合成、晶体结构及其与DNA作用方式的研究

周庆华，杨频*

(山西大学分子科学研究所化学生物学与分子工程教育部重点实验室太原 030006)

投稿日期:2005-08-29 修回日期:2005-12-19 发布日期:2006-04-25
通讯作者: 杨频

Synthesis, Crystal Structure and DNA Binding Studies of Zn(II) Complex with 1,3-Bis(benzimidazol-2-yl)-2-oxapropane

ZHOU Qing-Hua, YANG Pin*

(Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Institute of Molecular Science,
Shanxi University, Taiyuan 030006)

Received:2005-08-29 Revised:2005-12-19 Published:2006-04-25

Abstract

A Zn(II) complex of L₂Zn•(ClO₄)₂•2CH₃OH•H₂O (L＝1,3-bis(benzimidazol-2-yl)-2-oxapro- pane) has been synthesized and characterized by elemental analyses and X-ray single crystal diffraction. The Zn(II) environment in complex is distorted octahedron. The interaction of the complex with DNA has been investigated by using UV spectra, DNA melting, fluorescent spectra and viscosity. The results show that the Zn(II) complex can be partially intercalated into the double helix of DNA due to the planarity of the benzimidazole ring and the bulky structure of the complex.

Key words: DNA, Zn(II) complex, partial insertion

Cite this article

ZHOU Qing-Hua, YANG Pin*. Synthesis, Crystal Structure and DNA Binding Studies of Zn(II) Complex with 1,3-Bis(benzimidazol-2-yl)-2-oxapropane[J]. Acta Chimica Sinica, 2006, 64(8): 793-798.

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1,3-双(2-苯并咪唑基)-2-氧杂丙烷与锌配合物的合成、晶体结构及其与DNA作用方式的研究

Synthesis, Crystal Structure and DNA Binding Studies of Zn(II) Complex with 1,3-Bis(benzimidazol-2-yl)-2-oxapropane

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