A novel autocorrelation topological index (1^Q) based on the bioacivity valence (Ai) of atom i and substituent distance index (L) are derived in this paper. The quatitative structure-activity relationships (QSAR) studies are performed with the acute toxicities of 16～30 substituted aromatics (containing substituents such as : F， Cl, Br, I, NO2, OH, NH2,OCH3, CHO, CONH2, COCH3 and alkyl) and 1^Q, L. Their bivariate correlation coefficients for green algae, Scenedsmus obliquus, Rana Japonica tadpoles, Photobacterium phosphoreum, Pimephales are 0.9361, 0.9559, 0.9733, 0.9354, 0.9599 respectively. The estimated results with above QSAR models are all better than the relevant achievements of literatures.

Key words: AROMATIC HYDROCARBON, ENVIRONMENTAL POLLUTION, ACUTE TOXICITY, BIOLOGICAL ACTIVITY, ORGANIC POLLUTANTS, QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP