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Acta Chimica Sinica ›› 2010, Vol. 68 ›› Issue (03): 263-268. Previous Articles     Next Articles

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核壳型Fe3O4/Au粒子的制备及其在表面等离子体子共振传感器中的应用

王健，王丽英，孙颖，朱晓楠，徐昊妍，毕宁，张寒琦，曹彦波，王兴华，宋大千   

  1. (吉林大学化学学院 长春 130012)
  • 投稿日期:2009-04-08 修回日期:2009-09-10 发布日期:2010-02-20
  • 通讯作者: 宋大千 E-mail:songdq@jlu.edu.cn
  • 基金资助:

    国家自然科学基金（20727003）

Preparation of Core/Shell Fe3O4/Au Nanocomposite and Its Application to Surface Plasmon Resonance Biosensor

Wang Jian Wang Liying Sun Ying Zhu Xiaonan Xu Haoyan Bi Ning Zhang Hanqi Cao Yanbo Wang Xinghua Song Daqian*   

  1. (College of Chemistry, Jilin University, Changchun 130012)
  • Received:2009-04-08 Revised:2009-09-10 Published:2010-02-20

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The synthesis and characterization of core/shell Fe3O4/Au nanocomposite were performed. Furthermore, its application to a surface plasmon resonance (SPR) biosensor was mainly studied. The Fe3O4/Au nanocomposite coupled with rabbit anti-human IgG (anti-IgG) was trapped on the Au film by magnetic force and the Fe3O4/Au/anti-IgG sensing membrane was prepared. There is not a covalent link between the membrane and Au film, which simplifies the immobilization of the antibody and enhances the sensitivity of biosensor. The SPR biosensor exhibits a satisfactory response for human IgG in the concentration range of 1.25～20.00 μg•mL－1 and shows good reproducibility.

Key words: Fe3O4/Au nanocomposite, surface plasmon resonance (SPR), human IgG