Acta Chimica Sinica ›› 2014, Vol. 72 ›› Issue (12): 1209-1217.DOI: 10.6023/A14080568 Previous Articles     Next Articles

Review

基于蛋白和多肽为模板的贵金属纳米簇合成研究

杨维涛a, 郭伟圣a, 张兵波b, 常津a   

  1. a. 天津大学材料学院 纳米生物技术研究所 天津市材料复合与功能化重点实验室 天津 300072;
    b. 同济大学附属东方医院转化研究中心 同济大学医学院生物医学工程与纳米科学研究院 上海 200092
  • 投稿日期:2014-08-05 发布日期:2014-10-10
  • 通讯作者: 张兵波, 常津 E-mail:jinchang@tju.edu.cn;bingbozhang@tongji.edu.cn
  • 作者简介:杨维涛, 2012级硕博连读生, 主要研究方向为多肽模板法合成多功能贵金属纳米簇, 以及基于近红外CuInS2量子点的多功能荧光纳米探针的设计与合成、MRI造影剂等方面.郭伟圣, 2012级博士, 2010年毕业于天津大学, 取得材料工学学士学位.主要研究方向集中于无毒近红外量子点的制备、多功能纳米探针的设计及其在肿瘤诊断方面的应用.2013年, 作为联合培养博士公派前往美国国立卫生研究院(NIH)深造学习, 目前致力于研究纳米颗粒与生物分子的相互作用.
  • 基金资助:

    项目受国家自然科学基金(No.81371618)和上海市教委科技创新重点项目(14ZZ039)资助.

Synthesis of Noble Metal Nanoclusters Based on Protein and Peptide as a Template

Yang Weitaoa, Guo Weishenga, Zhang Bingbob, Chang Jina   

  1. a. Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University, Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072;
    b. Research Center for Translational Medicine, East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092
  • Received:2014-08-05 Published:2014-10-10
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Grant No. 81371618) and Key Innovation Project of Shanghai Municipal Education Commission (14ZZ039).

Noble metal nanoclusters (NMNCs) are the molecular aggregates, which are composed of several to one hundred atoms, and possess good biocompatibility, ultra small size (smaller than 2 nm), excellent physical and chemical properties, especially the strong photoluminescence, have aroused people's wide concern. Currently various kinds of methods to synthesize the NMNCs have been reported, and the NMNCs have been applied in many fields, such as bioimaging, electrochemiluminesence (ECL), biosensor and cell labeling. After BSA was the first protein to synthesize the Au nanoclusters, subsequently other kinds of similar protein and self-designed peptide appear. This review focuses on the advantages of this emerging method in recent years that choosing the protein and peptide as the template, simultaneously lists the protein and the peptide sequence reported in recent years, and explores the connection between the specific amino acids composition of protein or peptide and the wavelength, quantum yield (QY), size of NMNCs. In the end, we explain the prerequisits possessed of protein and peptide in synthesizing the NMNCs as well as predict the further development and the future of this synthesis method based on the protein and peptide as the template in the biomedical application.

Key words: noble metal, nanocluster, protein, peptide, fluorescence