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有机化学
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有机化学 ›› 2012, Vol. 32 ›› Issue (06): 1141-1145.DOI: 10.6023/cjoc1109222 上一篇    下一篇

研究简报

2-氨基-4,5-二取代烃嘧啶类衍生物的新合成方法

邓兰青a, 徐中海a, 尚云峰a, 戴文静a, 胡辉敏a, 邓穗平b, 欧阳健明b   

  1. a 岳阳职业技术学院 岳阳市中草药综合利用重点实验室 岳阳 414000;
    b 暨南大学生物矿化与结石病防治研究所 广州 510632
  • 收稿日期:2011-09-22 修回日期:2011-12-20 发布日期:2012-02-14
  • 通讯作者: 邓兰青 E-mail:denglq1111@126.com
  • 基金资助:
    国家自然科学基金(No. 30672103)和湖南省教育厅(No. 10C0336)资助项目.

A New Synthesis of 2-Amino-4,5-substituted Pyrimidine Derivatives

Deng Lanqinga, Xu Zhonghaia, Shang Yunfenga, Dai Wenjinga, Hu Huimina, Deng Suipingb, Ouyang Jianmingb   

  1. a Key Laboratory of Yueyang Chinese Herbal Utilization, Yueyang Vocational Technical College, Yueyang 414000;
    b Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632
  • Received:2011-09-22 Revised:2011-12-20 Published:2012-02-14
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 30672103) and the Fundation of Hunan Educational Committee (No. 10C0336).

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被引次数

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研究了2-氨基-4,5-二烃基取代嘧啶类衍生物的一个新的简易合成方法, 该方法以简单且廉价的4 个芳香醛和3个脂肪醛为原料, 经过四步反应得到12 个2-氨基-4,5-二烃基取代嘧啶类化合物, 总收率在40%～70%, 经氢核磁共振(1H NMR)、碳核磁共振(13C NMR)和高效液质联用(LC-MS)对其目标产物进行表征.

关键词: 2-氨基嘧啶, 芳香醛, 脂肪醛, 合成性

In this paper, a novel synthetic method for 2-amino-4,5-substituted pyrimidine derivatives was reported, which began from cheap and simple four aromatic aldehydes and three aliphatic aldehydes. 12 compounds of 2-amino-4,5-substituted pyrimidine derivatives were synthesized by four steps with yields of 40%～70%. The structures of terminational compounds were determined by 1H NMR, 13C NMR and LC-MS techniques.

Key words: 2-amino-pyrimidine, aromatic aldehyde, aliphatic aldehyde, synthesis