2-脱氧糖糖苷的化学合成进展

doi:10.6023/cjoc1202041

有机化学 ›› 2012, Vol. 32 ›› Issue (10): 1812-1826.DOI: 10.6023/cjoc1202041 上一篇下一篇

综述与进展

2-脱氧糖糖苷的化学合成进展

李仲振^a, 丁宁^b, 张伟^b, 王鹏^a, 李明^a, 李英霞^b

a 中国海洋大学医药学院教育部海洋药物重点实验室青岛 266003;
b 复旦大学药学院上海 201203

收稿日期:2012-02-04 修回日期:2012-04-20 发布日期:2012-05-21
通讯作者: 丁宁 E-mail:dingning@fudan.edu.cn
基金资助:
国家自然科学基金(Nos. 81072525, 21002014)、教育部博士点新教师基金(No. 20100071120051)、中央高校专项基金(No. 10FX061)资助项目.

Progress in the Chemical Synthesis of 2-Deoxy-glycosides

Li Zhongzhen^a, Ding Ning^b, Zhang Wei^b, Wang Peng^a, Li Ming^a, Li Yingxia^b

a Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003;
b School of Pharmacy, Fudan University, Shanghai 201203

Received:2012-02-04 Revised:2012-04-20 Published:2012-05-21
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 81072525, 21002014), the Research Fund for the Doctoral Program of Higher Education of China (No. 20100071120051), and the Fundamental Research Funds for the Central Universities (No. 10FX061).

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摘要/Abstract

2-脱氧糖糖苷是指糖苷中糖基单元的2位羟基被氢原子取代的糖苷, 广泛存在于天然产物中并具有多样的生物活性. 综述了近年来2-脱氧糖苷在化学合成方法方面的进展, 包括直接醚化法、直接糖苷化法、临时保护基法及非糖物质合成法等.

关键词: 2-脱氧糖苷, 寡糖, 化学合成方法

2-Deoxy-glycosides are monosaccharides in which the hydroxyl group at C-2 is replaced with a hydrogen atom. They exist widely in natural products and show various bioactivity. The recent advances in organic synthesis of 2-deoxy-glycosides are summarized mainly focusing on direct etherification, direct glycosidic bond formation, temporary protecting groups, synthesis from non-sugar and so on.

Key words: 2-deoxy-glycosides, oligosaccharides, chemosynthesis methodology

引用此文

李仲振, 丁宁, 张伟, 王鹏, 李明, 李英霞. 2-脱氧糖糖苷的化学合成进展[J]. 有机化学, 2012, 32(10): 1812-1826.

Li Zhongzhen, Ding Ning, Zhang Wei, Wang Peng, Li Ming, Li Yingxia. Progress in the Chemical Synthesis of 2-Deoxy-glycosides[J]. Chin. J. Org. Chem., 2012, 32(10): 1812-1826.

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2-脱氧糖糖苷的化学合成进展

Progress in the Chemical Synthesis of 2-Deoxy-glycosides

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