铜催化胺与1,3-二羰基化合物的缩合反应合成烯胺酮化合物

doi:10.6023/cjoc201301012

有机化学 ›› 2013, Vol. 33 ›› Issue (04): 860-865.DOI: 10.6023/cjoc201301012 上一篇下一篇

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铜催化胺与1,3-二羰基化合物的缩合反应合成烯胺酮化合物

瞿益萍, 王龙翔, 周晓玉, 冯秀娟, 包明

大连理工大学精细化工国家重点实验室大连 116023

收稿日期:2013-01-05 修回日期:2013-01-25 发布日期:2013-02-01
通讯作者: 冯秀娟 E-mail:fengxiujuan@dlut.edu.cn
基金资助:
国家自然科学基金(No. 21073025)资助项目.

Copper-Catalyzed Condensation Reaction of Amines with 1,3-Dicarbonyl Compounds to Produce Enaminones

Qu Yiping, Wang Longxiang, Zhou Xiaoyu, Feng Xiujuan, Bao Ming

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023

Received:2013-01-05 Revised:2013-01-25 Published:2013-02-01
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21073025).

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摘要/Abstract

报道了铜催化胺与1,3-二羰基化合物的缩合反应. 在CuCl催化剂的存在下, 胺与1,3-二羰基化合物的缩合反应, 可在四氢呋喃溶剂中、室温条件下顺利进行, 生成烯胺酮化合物, 收率为75%～98%. 合成了16种烯胺酮化合物3a～3p, 其中, 3p为未知化合物.

Copper-catalyzed condensation reaction of amines with 1,3-dicarbonyl compounds is described. The condensation reaction of amines with 1,3-dicarbonyl compounds proceeded smoothly in the presence of copper chloride (CuCl) catalyst at room temperature in tetrahydrofuran (THF) to produce enaminones in range of 75%～98% yields. Sixteen kinds of enaminones 3a～3p were prepared, and the 3p is an unknown product.

Key words: copper catalysis, amine, 1,3-dicarbonyl compound, enaminone, synthesis

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瞿益萍, 王龙翔, 周晓玉, 冯秀娟, 包明. 铜催化胺与1,3-二羰基化合物的缩合反应合成烯胺酮化合物[J]. 有机化学, 2013, 33(04): 860-865.

Qu Yiping, Wang Longxiang, Zhou Xiaoyu, Feng Xiujuan, Bao Ming. Copper-Catalyzed Condensation Reaction of Amines with 1,3-Dicarbonyl Compounds to Produce Enaminones[J]. Chin. J. Org. Chem., 2013, 33(04): 860-865.

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铜催化胺与1,3-二羰基化合物的缩合反应合成烯胺酮化合物

Copper-Catalyzed Condensation Reaction of Amines with 1,3-Dicarbonyl Compounds to Produce Enaminones

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