有机化学 ›› 0, Vol. ›› Issue (0): 0-0.DOI: 10.6023/cjoc201301025    

研究简报

1-(香豆素-3-酰基)愈创兰烃薁的合成及其抗菌活性

王道林a, 董哲a, 徐姣b, 李帝a   

  1. a 辽宁省功能化合物合成与应用重点实验室, 渤海大学化学化工与食品安全学院 锦州 121003;
    b 黑龙江中医药大学佳木斯学院 佳木斯 154007
  • 出版日期:2013-12-31 发布日期:2013-03-07
  • 通讯作者: 王道林, 徐姣 E-mail:wangdaolin@sina.com.cn
  • 基金资助:

    辽宁省科技厅(No.2011220022)和黑龙江中医药大学优秀创新人才支持计划资助项目.

Synthesis and Antibacterial Activity of 1-(Coumarin-3-carbonyl)guaiazulene Derivatives

Wang Daolina, Dong Zhea, Xu Jiaob, Li Dia   

  1. a Key Laboratory of Synthesis & Application of Functional Compound, College of Chemistry, Chemical Engineering & Food Safety, Bohai University, Jinzhou 121003;
    b Cosmetology Department, Heilongjiang University of Chinese Medicine,Jiamusi Institute, Jiamusi, 154007
  • Online:2013-12-31 Published:2013-03-07
  • Supported by:

    Project supported by the Science and Technology Department of Liaoning Province (No.2011220022), and the Innovation Talent Program of Heilongjiang University of Chinese Medicine.

在醋酸铵作用下, 通过1-氰乙酰基愈创兰烃薁与2-羟基苯甲醛类化合物的缩合反应, 合成了一系列1-(香豆素-3-酰基)愈创兰烃薁衍生物.该反应操作简单、条件温和、收率良好. 产物结构经NMR, IR, MS及元素分析数据得以证实. 对所得化合物进行了抗菌活性测试, 初步表明它们具有一定的活性。

关键词: 薁, 愈创兰烃薁, 香豆素, 合成, 抗菌活性

An efficient and easy method for the synthesis of 1-(coumarin-3-carbonyl)guaiazulene derivatives by the condensation of 1-cyanoacetylguaiazulene and 2-hydroxyaldehydes in the presence of ammonium acetate has been described. The structures of all target compounds have been confirmed by NMR, IR, MS spectra and elemental analysis, and the bioassay result indicated that some of the title compounds had relatively antibacterial activity.

Key words: azulene, guaiazulene, coumarin, synthesis, antibacterial activity