棠梨枝叶的化学成分研究

doi:10.6023/cjoc201303041

有机化学 ›› 2013, Vol. 33 ›› Issue (06): 1284-1290.DOI: 10.6023/cjoc201303041 上一篇下一篇

研究论文

棠梨枝叶的化学成分研究

赵冕^a, 蔡乐^a, 何健民^a,b, 尹田鹏^a, 隋迎春^a, 罗梦婷^a, 丁中涛^a

a 教育部自然资源药物化学重点实验室云南大学化学科学与工程学院昆明 650091;
b 保山学院资源环境学院保山 678000

收稿日期:2013-03-26 修回日期:2013-04-25 发布日期:2013-05-06
通讯作者: 丁中涛 E-mail:ztding@ynu.edu.cn
基金资助:
国家自然科学基金(No.21002084)和云南省自然科学基金(No.2010CD017)资助项目.

Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don

Zhao Mian^a, Cai Le^a, He Jianmin^a,b, Yin Tianpeng^a, Sui Yingchun^a, Luo Mengting^a, Ding Zhongtao^a

a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091;
b College of Resource and Environment, Baoshan University, Baoshan 678000

Received:2013-03-26 Revised:2013-04-25 Published:2013-05-06
Supported by:
Project supported by the National Natural Science Foundation of China (No.21002084), and the Natural Science Foundation of China of Yunnan Province (No.2010CD017).

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摘要/Abstract

从棠梨枝叶(Pyrus pashia Buch.-Ham.ex D.Don)的甲醇提取物中分离得到了17个化合物, 采用高分辨质谱、一维和二维核磁共振等现代波谱技术, 鉴定上述化合物的结构分别为: pashinin A (1), 天麻苷-7-O-顺式咖啡酸酯(2), 天麻苷-7-O-反式咖啡酸酯(3), 山奈酚-3-O-β-D-(6"-O-对香豆酸酯)吡喃葡萄糖苷(4), 山奈酚-3-O-β-D-(6"-O-顺式对香豆酰)吡喃葡萄糖苷(5), 天麻苷-7-O-对羟基苯甲酸酯(6), 熊果苷(7), robustaside B (8), 委陵菜酸(9), 蔷薇酸(10), 槲皮素3-O-β-D-吡喃葡萄糖苷(11), 2R,3R-二氢槲皮素(12), 木犀草素-4'-O-β-D-吡喃葡萄糖苷(13), 芹黄素-4'-O-β-D-吡喃葡萄糖苷(14), 5,7,4'-三羟基异黄酮-7-O-β-D-吡喃葡萄糖苷(15), 染料木素(16), 咖啡酸(17), 其中化合物1和2为新化合物, 化合物3为新的天然产物.除化合物17外, 其余化合物均首次从该植物中分离得到.化合物1～3的抗肿瘤细胞活性实验表明其没有体外肿瘤细胞生长抑制活性(IC₅₀ >40 μmol·L^-1); 抗HIV病毒(HIV-1_IIIB)实验显示: 化合物1有极弱的抗HIV-1的活性, 化合物4有弱的抗HIV-1的活性.

关键词: 棠梨, 枝叶, pashinin A, 天麻苷-7-O-顺式咖啡酸酯, 抗HIV-1活性

Seventeen compounds were isolated from the branches and leaves of Pyrus pashia Buch.-Ham.ex D.Don.On the basis of spectroscopic methods (HR-ESIMS, 1D- and 2D-NMR), their structures were identified as pashinin A (1), gastrodin-7-O-cis-caffeoyl ester (2), gastrodin-7-O-trans-caffeoyl ester (3), kaempferol-3-β-D-(6-O-trans-p-coumaroyl)glu- copyranoside (4), kaempferol-3-β-D-(6-O-cis-p-coumaroyl)glucopyranoside (5), gastrodin-7-O-p-hydroxybenzoyl ester (6), arbutin (7), robustaside B (8), tormentic acid (9), euscaphic acid (10), quercetin-3-O-β-D-glucopyranoside (11), 2R,3R-dihydyoquercetin (12), luteolin-4'-O-β-D-glucopyranoside (13), apigenin-4'-O-β-D-glucopyranoside (14), 5,7,4'-trihy- droxyisoflavone-7-O-β-D-glucopyranoside (15), genistein (16), caffeic acid (17).Among them, 1 and 2 were new compounds, 3 was a new natural product, 4～16 were isolated from this plant for the first time.Compounds 1～3 showed no cytotoxic effects on tumor cell (IC₅₀ >40 μmol·L^-1).1 and 4 exhibited weak anti-HIV-1 activities.

Key words: Pyrus pashia, branches and leaves, pashinin A, gastrodin-7-O-cis-caffeoyl ester, anti-HIV-1 activities

引用此文

赵冕, 蔡乐, 何健民, 尹田鹏, 隋迎春, 罗梦婷, 丁中涛. 棠梨枝叶的化学成分研究[J]. 有机化学, 2013, 33(06): 1284-1290.

Zhao Mian, Cai Le, He Jianmin, Yin Tianpeng, Sui Yingchun, Luo Mengting, Ding Zhongtao. Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don[J]. Chin. J. Org. Chem., 2013, 33(06): 1284-1290.

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棠梨枝叶的化学成分研究

Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don

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