有机化学 ›› 2013, Vol. 33 ›› Issue (11): 2341-2348.DOI: 10.6023/cjoc201306007 上一篇    下一篇

研究论文

TiCl4催化一锅法三组分合成β-氨基酮化合物

杨德利, 李加荣, 孙克宁, 路红燕, 刘明星, 史大昕   

  1. 北京理工大学化工与环境学院 北京 100081
  • 收稿日期:2013-06-06 修回日期:2013-07-10 发布日期:2013-07-26
  • 通讯作者: 史大昕 E-mail:shidaxin@bit.edu.cn
  • 基金资助:

    北京理工大学基础研究基金资助项目

One-Pot Three Components Synthesis of β-Amido Ketones

Yang Deli, Li Jiarong, Sun Kening, Lu Hongyan, Liu Mingxing, Shi Daxin   

  1. School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081
  • Received:2013-06-06 Revised:2013-07-10 Published:2013-07-26
  • Supported by:

    Project supported by the Foundation of Beijing Institute of Technology.

在酰氯辅助下、以四氯化钛为催化剂,不同的醛、酮和腈化物在室温三组分一锅合成了一系列β-氨基酮化合物. 考察了催化剂用量,反应温度和反应时间对产品收率的影响. 这种方法具有反应温和、操作简单、底物适用范围宽、产物收率高等优点.

关键词: β-氨基酮, 多组分合成, 四氯化钛

A series of β-amido-ketones were synthesized by one-pot three components condensation of various aldehydes, ketones and nitriles in the presence of TiCl4 with the assistance of acyl chloride at room temperature. The effects of amount of catalyst, reaction temperature and reaction time on the products yields were investigated. This methodology offers several ad-vantages, such as mild reaction condition, operational simplicity, suitable for wide range of substrates, and excellent yields.

Key words: β-amido ketones, multi-component synthesis, titanium tetrachloride