有机化学 ›› 2014, Vol. 34 ›› Issue (3): 584-588.DOI: 10.6023/cjoc201310016 上一篇    下一篇

研究简报

一种有效制备2-氨基-3,5-二硝基-6-氯吡啶及其衍生物的方法

马丛明a, 侯可辉a, 刘祖亮a, 姚其正a,b   

  1. a 南京理工大学化工学院 南京 210094;
    b 中国药科大学药学院 南京 210009
  • 收稿日期:2013-10-14 修回日期:2013-11-05 发布日期:2013-11-21
  • 通讯作者: 姚其正 E-mail:qz_yao@163.com
  • 基金资助:

    国家自然科学基金(No. 21102125)资助项目.

A Convenient Preparation Method for 2-Amino-3,5-dinitro-6-chloropyridine and Its Derivatives

Ma Congminga, Hou Kehuia, Liu Zulianga, Yao Qizhenga,b   

  1. a School of Chemical Engineering, Nanjing University of Science &Technology, Nanjing 210094;
    b School of Pharmacy, China Pharmaceutical University, Nanjing 210009
  • Received:2013-10-14 Revised:2013-11-05 Published:2013-11-21
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21102125).

研究了2-氨基-3,5-二硝基-6-氯吡啶(4)及其衍生物的制备新方法. 以廉价易得的2,6-二氯吡啶(1)为起始原料,通过硝化、氨化、硝化反应步骤得到中间体2-氨基-3,5-二硝基-6-氯吡啶(4),再与氨、叠氮化钠等亲核试剂反应分别得到2-氨基-3,5-二硝基吡啶-6-取代衍生物57. 研究表明该方法具有原料便宜易得、后处理操作简单和产品纯度高等优点.

关键词: 制备, 2,6-二氯吡啶, 2-氨基-3,5-二硝基-6-氯吡啶, 亲核取代

A novel preparation method for 2-amino-3,5-dinitro-6-chloropyridine (4) and its derivatives was described starting from cheap and easily available 2,6-dichloropyridine (1). Compound 4 was obtained by nitration, amination and again nitration reaction, followed by reacting with several nucleophilic reagents, such as ammonia, sodium azide to form 2-amino-3,5-dinitropyridine-6-substituted derivatives 57, respectively. The results showed that this synthetic route had the advantages of easy-obtained raw materials, simple work-up and high purity product.

Key words: preparation, 2,6-dichloropyridine, 2-amino-3,5-dinitro-6-chloropyridine, nucleophilic substitution