烟酰胺腺嘌呤二核苷酸(NAD+)类似物的合成及与NAD+依赖型酶相互作用进展

doi:10.6023/cjoc201508010

摘要/Abstract

烟酰胺腺嘌呤二核苷酸(NAD⁺)与NAD⁺依赖型酶间的相互作用在细胞氧化还原反应、能量代谢、信号转导过程中发挥着重要作用. NAD⁺依赖型酶利用共同的辅酶, 它们之间相互作用规律受到越来越广泛的关注. 主要针对NAD⁺类似物的合成及与NAD⁺依赖型酶相互作用研究的最新进展作一综述, 包括NAD⁺类似物的合成及其与天然NAD⁺依赖型酶相互作用、NAD⁺与突变酶相互作用及NAD⁺类似物与突变酶相互作用.

关键词: NAD⁺, NAD⁺类似物, NAD⁺依赖型酶, 相互作用

Interactions between nicotiamide adenine dinucleotide (NAD⁺) and NAD⁺-dependent enzyme play a crucial role in cellular redox state, energy metabolism, catabolism, anabolism and signal transduction. The rules of interaction between NAD⁺and NAD⁺-dependent enzyme have attracted increasing attention due to so many cellular processes are connected to NAD⁺. This review highlights some recent progresses in the fields of NAD⁺analogs synthesis and interactions with NAD⁺- dependent enzyme including the synthesis of NAD⁺analogs and its interactions with wild NAD⁺-dependent enzyme, interactions between NAD⁺and mutant enzymes, interactions between NAD⁺analogs and mutant enzymes.

Key words: NAD⁺, NAD⁺analog, NAD⁺-dependent enzyme, interaction

引用此文

侯淑华, 曲忠国, 钟克利, 边延江, 汤立军. 烟酰胺腺嘌呤二核苷酸(NAD⁺)类似物的合成及与NAD⁺依赖型酶相互作用进展[J]. 有机化学, 2016, 36(2): 297-305.

Hou Shuhua, Qu Zhongguo, Zhong Keli, Bian Yanjiang, Tang Lijun. Recent Advances in Nicotinamide Adenine Dinucluotide (NAD⁺) Analogs Synthesis and Their Interactions with NAD⁺-Dependent Enzymes[J]. Chin. J. Org. Chem., 2016, 36(2): 297-305.

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