二(β-二亚胺基)二价稀土配合物催化醛/酮与亚磷酸二乙酯的氢磷化反应

doi:10.6023/cjoc201603004

有机化学 ›› 2016, Vol. 36 ›› Issue (9): 2168-2174.DOI: 10.6023/cjoc201603004 上一篇下一篇

研究论文

二(β-二亚胺基)二价稀土配合物催化醛/酮与亚磷酸二乙酯的氢磷化反应

刘倩倩, 洪玉标, 郑煜, 薛明强

苏州大学材料与化学化工学部苏州 215123

收稿日期:2016-03-03 修回日期:2016-04-27 发布日期:2016-05-06
通讯作者: 薛明强 E-mail:xuemingqiang@suda.edu.cn
基金资助:
国家自然科学基金（No.21372171）资助项目.

Bis(β-diketiminato) Lanthanide(Ⅱ) Complexes-Catalyzed Hydro-phosphonylation of Aldehydes/Ketones and Diethyl Phosphite

Liu Qianqian, Hong Yubiao, Zheng Yu, Xue Mingqiang

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123

Received:2016-03-03 Revised:2016-04-27 Published:2016-05-06
Supported by:
Project supported by the National Natural Science Foundation of China (No.21372171).

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摘要/Abstract

研究了一系列二（β-二亚胺基）二价稀土配合物[Eu(L^2,6-ipr2)₂·CH₃C₆H₅,L^2,6-ipr2=[N(2,6-ⁱPr₂C₆H₃)C(Me)]₂CH^-(1);Eu(L^2,6-Me2)₂(THF),L^2,6-Me2=[N(2,6-Me₂C₆H₃)C(Me)]₂CH^-(2);Eu(L^2,4,6-Me3)₂(THF),L^2,4,6-Me3=[N(2,4,6-Me₃C₆H₂)-C(Me)]₂CH^-(3);Eu(L^2,6-ipr2_Ph)₂,L^2,6-ipr2_Ph=[(2,6-ⁱPr₂C₆H₃)NC(Me)CHC(Me)N(C₆H₅)]^-(4);Sm(L^2,6-ipr2)2·CH₃C₆H₅(5);Yb(L^2,6-ipr2_Ph)₂(6);Yb(L^2-Me)2(THF),L^2-Me=[N(2-MeC₆H₄)C(Me)]₂CH^-(7)]对醛/酮与亚磷酸二乙酯的氢磷化反应的催化行为.发现所有配合物都可以在温和条件下，高效地催化芳醛以及杂环芳醛与亚磷酸二乙酯的氢磷化反应，在催化剂用量为0.08 mol%，25℃，无溶剂条件下反应5 min，α-羟基膦酸酯的收率可以达到90%~99%.催化活性有赖于β-二亚胺基的结构，其活性顺序为L^2，6-Me2< L^{2，4，6-Me3}< L^2，6-ipr2≈L^2，6-ipr2_Ph.该催化体系具有优秀的醛底物适应能力.这类二价稀土配合物也可以有效地催化未活化的酮与亚磷酸二乙酯的反应，并显示良好的底物适应能力.

关键词: β-二亚胺基, 二价稀土配合物, 氢磷化反应, 醛、酮

The hydrophosphonylation of aldehydes/ketones was explored by use of seven bis(β-diketiminato) lanthanide(Ⅱ) complexes[Eu(L^2,6-ipr2)₂·CH₃C₆H₅, L^2,6-ipr2=[N(2,6-ⁱPr₂C₆H₃)C(Me)]₂CH^- (1); Eu(L^2,6-Me2)₂(THF), L^2,6-Me2=[N(2,6-Me₂C₆H₃)C(Me)]₂CH^- (2); Eu(L^2,4,6-Me3)₂(THF), L^2,4,6-Me3=[N(2,4,6-Me₃C₆H₂)C(Me)]₂CH^- (3); Eu(L^2,6-ipr2_Ph)₂, L^2,6-ipr2_Ph=[(2,6-ⁱPr₂C₆H₃)NC(Me)CHC(Me)N(C₆H₅)]^-(4); Sm(L^2,6-ipr2)₂·CH₃C₆H₅ (5); Yb(L^2,6-ipr2_Ph)₂ (6); Yb(L^2-Me)₂(THF), L^2-Me=[N(2-MeC₆H₄)C(Me)]₂CH^- (7)] as the catalysts. All complexes were found to be able to catalyze the hydrophosphonylation between aromatic or heterecycle aldehyde and diethyl phosphite with high activity under wild conditions. All the reactions gave the products in 90%~99% yields using 0.08 mol% of complex 7 at 25℃ under solvent-free. The catalyst activity was found to depend on the β-diketiminato ligands with the sequence of L^2,6-Me22,4,6-Me32,6-ipr2≈L^2,6-ipr2_Ph. This catalyst system showed a wide scope of aldehydes. Besides, bis(β-diketiminato) lanthanide(Ⅱ) complexes could also efficiently catalyze the hy-drophosphonylation of unactive ketones with diethyl phosphite and showed a good substrate scope.

Key words: β-diketiminato, lanthanide(Ⅱ) complexes, hydrophosphonylation, aldehydes/ketones

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刘倩倩, 洪玉标, 郑煜, 薛明强. 二(β-二亚胺基)二价稀土配合物催化醛/酮与亚磷酸二乙酯的氢磷化反应[J]. 有机化学, 2016, 36(9): 2168-2174.

Liu Qianqian, Hong Yubiao, Zheng Yu, Xue Mingqiang. Bis(β-diketiminato) Lanthanide(Ⅱ) Complexes-Catalyzed Hydro-phosphonylation of Aldehydes/Ketones and Diethyl Phosphite[J]. Chin. J. Org. Chem., 2016, 36(9): 2168-2174.

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二(β-二亚胺基)二价稀土配合物催化醛/酮与亚磷酸二乙酯的氢磷化反应

Bis(β-diketiminato) Lanthanide(Ⅱ) Complexes-Catalyzed Hydro-phosphonylation of Aldehydes/Ketones and Diethyl Phosphite

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