川西獐牙菜中两个新的链状单萜类化合物

doi:10.6023/cjoc201603038

有机化学 ›› 2016, Vol. 36 ›› Issue (9): 2216-2219.DOI: 10.6023/cjoc201603038 上一篇下一篇

研究简报

川西獐牙菜中两个新的链状单萜类化合物

曹团武^a,b, 何康^a, 耿长安^a, 张雪梅^a, 周俊^a, 陈纪军^a

a 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室昆明 650201;
b 长江师范学院化学化工学院武陵山天然药物研究与开发实验室涪陵 408100

收稿日期:2016-03-23 修回日期:2016-04-29 发布日期:2016-06-01
通讯作者: 陈纪军 E-mail:chenjj@mail.kib.ac.cn
基金资助:
国家杰出青年科学基金（No.81025023）资助项目.

Two New Linear Monoterpenoids from Swertia mussotii

Cao Tuanwu^a,b, He Kang^a, Geng Chang'an^a, Zhang Xuemei^a, Zhou Jun^a, Chen Jijun^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201;
b Laboratory of Natural Medicine Research and Development in Wuling Mountain, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100

Received:2016-03-23 Revised:2016-04-29 Published:2016-06-01
Supported by:
Project supported by the National Science Foundation of China for Distinguished Young Scholar (No.81025023).

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摘要/Abstract

利用多种色谱分离方法对川西獐牙菜的化学成分进行研究，从其全草的乙醇提取物中分离得到四个化合物，应用HR-ESIMS，1D和2D NMR，IR，UV等多种现代波谱技术确定了这些化合物的化学结构，经鉴定分别为（S，2E，6E）-2，6-二甲基-4，8-二羟基辛烷-2，6-二烯酸（1），（S，2E，6E）-2，6-二甲基-4-羟基-8-甲酰氧基辛烷-2，6-二烯酸（2），swerimilegenins B和C（3和4）.化合物1和2为两个新的链状单萜类化合物，分别命名为川西獐牙菜酸C和D，化合物3和4是两个不常见的C9骨架的环烯醚萜，为首次从该植物中分离得到.

关键词: 龙胆科, 川西獐牙菜, 链状单萜, 川西獐牙菜酸C和D

Investigation on Swertia mussotii resulted in four compounds by means of various chromatographic techniques (silica gel, Sephadex LH-20, RP-LC and Pre-HPLC). Their structures were determined as (S,2E,6E)-4,8-dihydroxy-2,6-dime-thylocta-2,6-dienoic acid (1), (S,2E,6E)-8-(formyloxy)-4-hydroxy-2,6-dimethylocta-2,6-dienoic acid (2), swerimilegenins B and C (3 and 4) on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D- and 2D-NMR. Among them, compounds 1 and 2 are two new linear monoterpenoids named as swerimusic acids C (1) and D (2), compounds 3 and 4 are two unusual known secoiridoid aglycones of C₉-skeleton obtained for the first time from this plant. Compounds 1~4 were evaluated for their anti-Hepatitis B Virus (HBV) activities on HepG2.2.15 cells line in vitro, but these compounds showed no anti-HBV activity at the maximal tesing concentration. Herin, we only report the isolation and structure elucidation of these compounds.

Key words: Gentianaceae, Swertia mussotii, linear monoterpenoid, swermusic acids C and D

引用此文

曹团武, 何康, 耿长安, 张雪梅, 周俊, 陈纪军. 川西獐牙菜中两个新的链状单萜类化合物[J]. 有机化学, 2016, 36(9): 2216-2219.

Cao Tuanwu, He Kang, Geng Chang'an, Zhang Xuemei, Zhou Jun, Chen Jijun. Two New Linear Monoterpenoids from Swertia mussotii[J]. Chin. J. Org. Chem., 2016, 36(9): 2216-2219.

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参考文献

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川西獐牙菜中两个新的链状单萜类化合物

Two New Linear Monoterpenoids from Swertia mussotii

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