有机化学    

研究论文

可见光引发炔烃双官能化反应构筑菲类化合物

李梦倩, 吕喆, 王少君, 韩宇轩, 崔秀灵*   

  1. 华侨大学生物医学学院 分子药物教育部工程研究中心 福建省分子医学重点实验室 福建省高校精准医学与分子诊断重点实验室 厦门市海洋与基因药物重点实验室 厦门 361021
  • 收稿日期:2024-07-03 修回日期:2024-08-13

Easy access to phenanthrenes through photoinduced difunctionalization of alkynes

Li Mengqian, Lv Zhe, Wang Shaojun, Han Yuxuan, Cui Xiuling*   

  1. Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021
  • Received:2024-07-03 Revised:2024-08-13
  • Contact: *E-mail: cuixl@hqu.edu.cn.
  • Supported by:
    Fujian Province (3502ZCQXT2021006), the 111 project (BC2018061) and the Open Research Fund of Academy of Advanced Carbon Conversion Technology, Huaqiao University (AACCT0007).

本文首次报道酮酯作为双官能团化试剂,在可见光下与二芳基炔烃反应,以高产率获得了一系列含有酰基和酯基的菲类化合物。该策略不需要添加额外的光催化剂以及添加剂,具有优秀的区域选择性、高效率和原子经济性。

关键词: 可见光促进, 双官能化反应, 碳-碳键活化, 菲类化合物

For the first time, ketoesters were successfully utilized as the bifunctionalization reagents to react with diaryl alkynes under visible light and photocatalyst or additives free conditions. A range of phenanthrenes containing acyl and ester groups were obtained in high yields. This protocol features with excellent regioselectivity, high efficiency, and atomic economy.

Key words: visible-light-promoted, bifunctional reaction, carbon-carbon bond activation, phenanthrenes