钯催化羧基导向的C(sp2)—H键烷基化/环化合成2-(1-异色满酮-3-基)乙醛衍生物

doi:10.6023/cjoc202410013

有机化学 ›› 2024, Vol. 44 ›› Issue (11): 3556-3563.DOI: 10.6023/cjoc202410013 上一篇下一篇

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钯催化羧基导向的C(sp²)—H键烷基化/环化合成2-(1-异色满酮-3-基)乙醛衍生物

王悦, 杨旭艳, 刘添雨, 李团结^*(), 张凯, 姚昌盛^*()

江苏师范大学化学与材料科学学院江苏徐州 221116

收稿日期:2024-10-22 修回日期:2024-11-20 发布日期:2024-11-25
基金资助:
国家自然科学基金(21772070)

Palladium-Catalyzed Synthesis of 2-(1-Isochromen-3-yl)acetalde-hydes via Carboxyl-Directed C(sp²)—H Alkylation/Annulation

Yue Wang, Xuyan Yang, Tianyu Liu, Tuanjie Li^*(), Kai Zhang, Changsheng Yao^*()

School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, Jiangsu 221116

Received:2024-10-22 Revised:2024-11-20 Published:2024-11-25
Contact: *E-mail:ltj2008@jsnu.edu.cn;csyao@jsnu.edu.cn
Supported by:
National Natural Science Foundation of China(21772070)

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摘要/Abstract

在醋酸钯催化下, 以芳酸和碳酸乙烯亚乙酯为原料, 通过羧基导向的C—H键烷基化/环化实现了2-(1-异色满酮-3-基)乙醛衍生物的合成. 该方法具有原料简单易得, 操作简便等优点, 为该类异色满酮衍生物的合成提供了一种有效方法.

关键词: 醋酸钯, 芳酸, 碳酸乙烯亚乙酯, 异色满酮

A Pd(OAc)₂-catalyzed efficient synthesis of 2-(1-isochromen-3-yl)acetaldehyde derivatives was achieved by the carboxyl-directed C—H bond alkylation/annulation of aryl acids with vinyl ethylene carbonate. This method has the advan- tages of ready availability of starting materials and operational simplicity, providing an alternative access to isochroman-1-one derivatives.

Key words: palladium acetate, aryl acid, vinyl ethylene carbonate, isochroman-1-one

引用此文

王悦, 杨旭艳, 刘添雨, 李团结, 张凯, 姚昌盛. 钯催化羧基导向的C(sp²)—H键烷基化/环化合成2-(1-异色满酮-3-基)乙醛衍生物[J]. 有机化学, 2024, 44(11): 3556-3563.

Yue Wang, Xuyan Yang, Tianyu Liu, Tuanjie Li, Kai Zhang, Changsheng Yao. Palladium-Catalyzed Synthesis of 2-(1-Isochromen-3-yl)acetalde-hydes via Carboxyl-Directed C(sp²)—H Alkylation/Annulation[J]. Chinese Journal of Organic Chemistry, 2024, 44(11): 3556-3563.

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钯催化羧基导向的C(sp²)—H键烷基化/环化合成2-(1-异色满酮-3-基)乙醛衍生物

Palladium-Catalyzed Synthesis of 2-(1-Isochromen-3-yl)acetalde-hydes via Carboxyl-Directed C(sp²)—H Alkylation/Annulation

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