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有机化学
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有机化学 ›› 1992, Vol. 12 ›› Issue (6): 605-607. 上一篇    下一篇

研究论文

3-氨基-5-取代苯氨基-6-苯基-1,2,4-三嗪的合成

陆忠娥;万军;陈克潜   

  1. 苏州大学化学系
  • 发布日期:1992-12-25

Synthesis of 3-amino-5-substituted phenylamino-6- phenyl- 1, 2, 4 -triazines

LU ZHONGE;WAN JUN;CHEN KEQIAN   

  • Published:1992-12-25

被引次数

15

3-氨基-1,2,4-三嗪化合物具有广泛的生理活性,如:治疗支气管扩张、抑制乳酸菌和症原虫繁殖杀菌等,因此,研究这类化合物合成方法应运而生。本文以苯甲酰基硫代甲酰胺为原料,进一步合成了氨基-5-取代苯氨基-6-苯基-1,2,4-三嗪。

关键词: 杀菌性, 苯胺 P, 支气管扩张, 氨基胍 P, 苯 P, 三嗪胺 P, 三嗪 P, 硫代甲酰胺

A new synthetic method of 3-amino-5-substituted phenylamino-6-phenyl-1,2,4-triazines was reported. Benzoylthioformanilides were first condensed with aminoguanidine dihydrochloride in slightly acidic medium, then refluxed in alkaline medium (pH 8~9) to give title compounds by the elimination of hydrogen sulfide. Nine 1,2,4-triazines I (R = Ph, substituted Ph) were synthesized by this reaction in good yields.

Key words: AMINOGUANIDINE P, BENZAMINE P, BRONCHIECTASIS, BENZENE P, AMINOTRIAZINE P, TRIAZINE P, THIOFORMAMIDE

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