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有机化学 ›› 1993, Vol. 13 ›› Issue (3): 282-285. 上一篇 下一篇
研究论文
朱有成
发布日期:
ZHU YOUCHENG
Published:
文章分享
正电子激发断层成象(PET)是体内基本生物和生理过程研究的有力工具.合成短命放射示踪剂的目的是发展PET探针,本文综述了各种类型的短命放射示踪剂的合成.
关键词: 诊断剂, 放射线示踪剂, 正电子激发断层成像
Positron emission tomog. (PET) has become a powerful tool for non-invasive investigations of basic biol. and physiol. processes in vivo, for example: blood flow, transport and metabolism of natural substrates and localization and characterization of receptor systems. The aim of the synthesis of short-lived radiotracers is to develop the PET probes. Cyclotron-produced 11C(t1/2:20min), 13N(t1/2:10min), 15O(t1/2:2min) and 18F(t1/2:110 min) are gaining ever increasing attention and being actively utilized in clin. research and application, because they could be incorporated into naturally occurring biomols. or drugs of various class without alteration of the compounds' defined functions in living systems. During recent years many 11C and 18F-labeled ligands have been synthesized for a no. of receptor systems such as opiate, dopamine, serotonin, benzodiazepine, histamine, nicotine and muscarine. Ohmefentanyl, a new, highly potent and selective agonist for opiate m-receptor found in the authors' laboratory, was labeled with carbon-11 in CEA, France.
Key words: DIAGNOSTICUM
中图分类号:
R98
朱有成. 短命辐射示踪剂的合成[J]. 有机化学, 1993, 13(3): 282-285.
ZHU YOUCHENG. Synthesis of short-lived radiotracers[J]. Chin. J. Org. Chem., 1993, 13(3): 282-285.
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