有机化学 ›› 2000, Vol. 20 ›› Issue (2): 198-201. 上一篇    下一篇

研究论文

PTC法合成5-芳基-2-呋喃甲酸四乙酰葡萄糖酯

刘明国;童开发;罗光富;廖全斌;付莎莉   

  1. 湖北三峡学院化学系;武汉大学化学系.武汉(430072)
  • 发布日期:2000-04-25

Synthesis of tetraacetyl glucosyl esters of 5-aryl-2-furoic acids by phase transfer catalysis

Liu Mingguo;Tong Kaifa;Luo Guangfu;Liao Quanbin;Fu Shali   

  1. Wuhan Univ, Dept Chem.Wuhan(430072)
  • Published:2000-04-25

采用PTC法合成了4个5-芳基-2-呋喃甲酸四乙酰葡萄糖酯,通过元素分析、IR、^1^HNMR及MS确证了糖酯的结构,并试验了所合成的糖酯的杀菌活性。通过对糖酯化合物的^1HNMR谱图中糖环碳1位质子的化学位移及偶合常数分析,结合IR谱图中糖环C1-H的弯曲振动吸收,确证它们均为β型异构体。

关键词: 呋喃甲酸P, 葡萄糖P, 元素分析, 红外分光光度法, 质子磁共振谱法, 质谱法, 相转移催化, 结构表征, 杀菌活性

Four new tetraacetyl glucosyl esters of 5- aryl -2-furoic acids were synthesized under phase transfer conditions, characterized by elemental analysis, IR, ^1H NMR and MS spectroscopy, and tested for the antibacterial activity. The ^1H NMR spectra showed that they were β-anomer. The PTC method has the advantages of mild reaction conditions, easy seperation of products and high stereosselectivity.

Key words: FURANCARBOXYLIC ACID P, PYRANE P, ELEMENTAL ANALYSIS, INFRARED SPECTROPHOTOMETRY, PROTON MAGNETIC RESONANCE SPECTROMETRY, MASS SPECTROGRAPHY, PHASE TRANSFER CATALYSIS, STRUCTURE CHARACTERISTICS

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