有机化学 ›› 2000, Vol. 20 ›› Issue (5): 783-786. 上一篇    下一篇

研究论文

β-炔基烯醇磷酸酯和二烷基铜锂试剂反应合成烯 炔类化合物

黄小根;林祥杰;丁贻祥   

  1. 中国科学院上海有机化学研究所.上海(200032)
  • 发布日期:2000-10-25

Novel synthesis of enynes by the reaction of β-alkynylenol phosphates with lithium dialkylcuprate

Huang Xiaogen;Lin Xiangjie;Ding Yixiang   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032)
  • Published:2000-10-25

提出了合成烯炔类化合物的新路线,联烯基酮(或炔基酮)经磷酸化生成β-炔基烯醇磷酸酯中间体,铜锂试剂的碳负离子取代后者的磷酰基得到烯炔化合物,产物以保留构型为主。

关键词: 炔烃P, 烯醇P, 磷酸酯类, 铜锂试剂, 烯炔化合物, 炔基酮, 联烯基酮

Under Atherton-Todd condition (NaH/CCl~4/(EtO)~2PHO), allenyl ketones can give the Z-isomer of β-alkynylenol phosphates, which were transformed successfully into enynes compounds with predominated E-configuration by the reaction with R~1CuLi.

Key words: ALKYNE P, ENOLS P, PHOSPHORIC ACID ESTER

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