有机化学 ›› 2004, Vol. 24 ›› Issue (4): 447-449. 上一篇    下一篇

研究简报

研磨法合成α,β-不饱和酮

王书香*, 李记太, 王振华   

  1. 河北大学化学与环境科学学院 保定 071002
  • 收稿日期:2003-05-26 修回日期:2003-08-26 接受日期:2003-10-20 发布日期:2022-09-19
  • 基金资助:
    河北省教育厅基金(No. 2001104)资助项目

Synthesis of α,β-Unsaturated Ketones by Grinding Method

WANG, Shu-Xiang*, LI, Ji-Tai, WANG, Zhen-Hua   

  1. College of Chemistry and Environmental Science, Hebei University, Baoding 071002
  • Received:2003-05-26 Revised:2003-08-26 Accepted:2003-10-20 Published:2022-09-19
  • Contact: *E-mail: hbdxxbz@mail.hbu.edu.cn; Tel: 0312-5079361.

将苯乙酮、芳香醛与KF-Al2O3 置于研钵中,在无溶剂条件下,室温研磨5 min 后放置一定时间,得到收率94%~98%的α,β-不饱和酮.该法反应条件温和,操作简便,KF-Al2O3可回收再利用.

关键词: 芳香醛, 苯乙酮, α,β-不饱和酮, 和成, 研磨

Using KF-Al2O3 (basic) as catalyst the Claisen-Schmidt condensation of acetophenone with aromatic aldehydes proceeded smoothly by simple mixing and grinding under solvent-free conditions at room temperature to give α,β-unsaturated ketones in high yields (94%~98%), and KF-Al2O3 could be recovered and reused.

Key words: acetophenone, aromatic aldehyde, α,β-unsaturated ketone, synthesis, grinding method