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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (06): 654-659. 上一篇    下一篇

研究论文

合欢皮中两个新八糖苷的分离鉴定和活性研究

邹坤1,2，崔景荣3，冉福香3，王邠1
赵玉英*,1，张如意1，郑俊华1   

  1. (1北京大学药学院天然药物学系 北京 100083)
    (2三峡大学化学与生命科学学院 宜昌 443000)
    (3北京大学药学院天然药物及仿生药物国家重点实验室 北京 100083)
  • 收稿日期:2004-04-12 修回日期:2004-12-06 发布日期:2005-05-30
  • 通讯作者: 赵玉英

Structures and Activity of Two Novel Saponins from Albiza julibrissin

ZOU Kun1, CUI Jing-Rong3 , RAN Fu-Xiang3, WANG Bin1
ZHAO Yu-Ying*1, ZHANG Ru-Yi1, ZHENG Jun-Hua1   

  1. (1 School of Pharmaceutical Sciences, Peking University, Beijing 100083)
    (2 College of Chemistry and Life Sciences, China Three Gorges University, Yichang 443000)
    (3 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences,
    Peking University, Beijing 100083)
  • Received:2004-04-12 Revised:2004-12-06 Published:2005-05-30

PDF

1306

被引次数

24

从合欢皮95%乙醇提取物中分离得到2个新的八糖苷(1, 2), 经化学方法与光谱分析将其结构鉴定为3-O-[β-D-吡喃木糖基-(1→2)-α-L-吡喃阿拉伯糖基-(1→6)-β-D-吡喃葡萄糖基]-21-O-[(6S)-2-反式-2-羟甲基-6-甲基-6-O-β-D-吡喃鸡纳糖基-2,7-辛二烯酸基]-金合欢酸-28-O-β-D-吡喃葡萄糖基-(1→3)-[α-L-呋喃阿拉伯糖基-(1→4)]-α-L-吡喃鼠李糖基- (1→2)-β-D-吡喃葡萄糖基酯(1)和3-O-[β-D-吡喃木糖基-(1→2)-α-L-吡喃阿拉伯糖基-(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖基]-21-O-[(6S)-2-反式-2-羟甲基-6-甲基-6-O-β-D-吡喃鸡纳糖基-2,7-辛二烯酸基]-金合欢酸-28-O-β-D-吡喃葡萄糖基-(1→3)-[α-L-呋喃阿拉伯糖基-(1→4)]-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖基酯(2), 分别命名为合欢皂苷J25 (1, Julibroside J25)和合欢皂苷J22 (2, Julibroside J22). 1和2在体外对4种人癌细胞增殖有明显的抑制作用.

关键词: 合欢皮, 合欢皂苷J25, 三萜皂苷, 合欢皂苷J22, 乙酰氨基糖苷

Two triterpene saponins acylated with monoterpenoid were isolated from the stem barks of Albizia julibrissin. Their structures were identified as 3-O--D-xylopyranosyl-(1→2)--L-arabinopyranosyl- (1→6)-6--D-glucopyrano-syl-21-O-[(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O-D-quinovopyranosyl- 2,7-octadienoyl]-acacic acid-28-O--D-glucopyranosyl-(1→3)-[α-2-arabinofuranosyl-(1→4)-α-L-rhomno- pyranosyl-(1→2)--D-glucopyranosylester (1) and 3-O--D-xylopyranosyl-(1→2)--L- arabinopyranosyl- (1→6)--D-2-deoxy-2-acetamidoglucopyranosyl-21-O-[(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O--D- quinovopyranosyl-2,7-octadienoyl]-acacic acid-28-O--D-glucopyranosyl-(1→3)--L-arabinofuranosyl- (1→4)--L-rhamnopyranosyl-(1→2)--D-glucopyranosyl ester (2) based on chemical and spectroscopic methods, respectively, named as Julibrosides J25 and J22. Julibrosides J25 and J22 showed marked activities against four kinds of cancer cell lines in a concentration of 100 g/mL assayed by SRB method.

Key words: Albizia julibrissin, acetamidoglucoside, julibroside J25, julibroside J22, triterpenoid saponin