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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (08): 940-943. 上一篇    下一篇

研究论文

1,1-二取代炔丙醇氯代产物与4-甲基-7-羟基香豆素的异常缩合产物

张倩，陈瑛，夏鹏*   

  1. (复旦大学药学院药物化学教研室 上海 200032)
  • 收稿日期:2004-06-10 修回日期:2005-02-23 发布日期:2005-07-30
  • 通讯作者: 夏鹏

Unusual Products from the Reaction of Chlorides of 1,1-DisubstitutedPropargyl Alcohols with 4-Methyl-7-hydroxycoumarin

ZHANG Qian, CHEN Ying, XIA Peng*   

  1. (Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 200032)
  • Received:2004-06-10 Revised:2005-02-23 Published:2005-07-30
  • Contact: XIA Peng

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报道了一类1,1-二取代炔丙醇(1)氯代产物与4-甲基-7-羟基香豆素反应的异常缩合产物. 一些实验数据表明1,1-二取代炔丙醇(1)的氯代反应中有一类未见报道的2,4-二氯-2-烯化合物(5)生成.

关键词: 2,4-二氯-2-烯烃化合物, 4-甲基-7-羟基香豆素, α-氯炔, 1,1-二取代炔丙醇

This paper reported a kind of unusual products from the reaction of chlorides of 1,1-disubstituted propargyl alcohols with 4-methyl-7-hydroxycoumarin. Some experimental data implied the formation of corresponding unreported 2,4-dichloro-but-2-enes in the chlorination of 1,1-disubstituted propargyl alcohols with SOCl2 or HCl.

Key words: 4-methyl-7- hydroxycoumarin, 1,1-disubstituted propargyl alcohol, 2,4-dichloro-but-2-ene, propargyl chloride