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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (12): 1602-1605. 上一篇    下一篇

研究简报

新型含环状α-羟基膦酸酯的N1-(四氢呋喃-2-基)-5-氟尿嘧啶衍生物的合成

石德清*，魏佳，谭效松   

  1. (华中师范大学化学学院 教育部农药与化学生物学重点实验室 武汉 430079)
  • 收稿日期:2005-03-15 修回日期:2005-06-20 发布日期:2005-11-30
  • 通讯作者: 石德清

Synthesis of Novel 1-Furanidin-2'-yl-5-fluorouracil Derivatives of Cyclic α-Hydroxyphosphonates

SHI De-Qing*, WEI Jia, TAN Xiao-Song   

  1. (Key Laboratory of Pesticide and Chemical Biology of Ministry of Education of China, College of Chemistry,
    Central China Normal University, Wuhan 430079)
  • Received:2005-03-15 Revised:2005-06-20 Published:2005-11-30
  • Contact: SHI De-Qing

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通过N1-(2-呋喃烷基)-N3-羟乙基-5-氟尿嘧啶的Moffatt氧化, 再与亚磷酸酯的加成反应合成得到8个新型含环状α-羟基膦酸酯的N1-(四氢呋喃-2-基)-5-氟尿嘧啶衍生物, 采用IR, 1H NMR, 31P NMR, MS和元素分析对其结构进行了表征.

关键词: 5-氟尿嘧啶, α-羟基膦酸酯, 抗肿瘤药物

ight novel 5-fluorouracil derivatives containing the unit of α-hydroxyphosphonates were synthesized via the addition reactions of cyclic phosphates to 1-furanidin-2'-yl-3-formylmethyl-5-fluorouracil. The structures of the products were confirmed by IR, 1H NMR, 31P NMR, MS spectra and elemental analyses.

Key words: cyclic α-hydroxyphosphonates, 1-furanidin-2'-yl-5-fluorouracil, antitumor drug