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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (02): 211-214. 上一篇    下一篇

研究论文

磺氨基醇手性配体的合成及钛配合物催化二乙基锌对醛的不对称加成反应

惠新平*，乔仁忠，许鹏飞   

  1. (兰州大学功能有机分子化学国家重点实验室 兰州 730000)
  • 收稿日期:2005-02-05 修回日期:2005-08-29 发布日期:2006-01-21
  • 通讯作者: 惠新平

Synthesis of Sulfonylated Amino Alcohols and Asymmetric Addition of Diethylzinc to Aldehydes Catalyzed by Titanium Complexes

HUI Xin-Ping*,QIAO Ren-Zhong,XU Peng-Fei   

  1. (State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000)
  • Received:2005-02-05 Revised:2005-08-29 Published:2006-01-21
  • Contact: HUI Xin-Ping

PDF

1450

被引次数

13

合成了手性磺氨基醇配体3～5, 将这些配体和Ti(O-i-Pr)4应用于二乙基锌对醛的不对称加成反应, 获得了好的对映选择性, ee值最高为91%.

关键词: 磺氨基醇, (＋)-10-樟脑磺酰氯, Ti(O-i-Pr)4, 二乙基锌

Sulfonylated amino alcohols 3～5 were prepared and the asymmetric addition of di-ethylzinc to aldehydes catalyzed by titanium complexes of those ligands was carried out. Good enantiose-lectivities were obtained with ee values up to 91%.

Key words: (＋)-10-camphorsulfonyl chloride, sulfonylated amino alcohol, diethylzinc, Ti(O-i-Pr)4