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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (04): 537-541. 上一篇    下一篇

研究简报

新型3-芳甲基-5-芳氧甲基丁内酯的合成及其抑制肺癌细胞生长活性评价

沙磊1，赵宝祥*,1，范传东2，谭伟1，李勋1，苗俊英*,2   

  1. (1山东大学化学与化工学院有机化学研究所 济南 250100)
    (2山东大学生命科学学院发育生物学研究所 济南 250100)
  • 收稿日期:2005-05-18 修回日期:2005-10-25 发布日期:2006-03-31
  • 通讯作者: 苗俊英

Synthesis and Primary Evaluation of Lung Cancer Cell Growth In-hibitory Activity of Novel 3-Arylmethyl-5-aroxymethylbutyrolactones

SHA Lei1,ZHAO Bao-Xiang*,1,FAN Chuan-Dong2,TAN Wei1
LI Xun1,MIAO Jun-Ying*,2   

  1. (1 Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100)
    (2 Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100)
  • Received:2005-05-18 Revised:2005-10-25 Published:2006-03-31
  • Contact: MIAO Jun-Ying

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被引次数

9 | 3

通过2-芳氧甲基环氧烷与α-芳甲基丙二酸二乙酯在乙醇钠条件下反应, 合成了8个新型3-芳甲基-5-芳氧甲基丁内酯, 收率为13%～81%. 由IR, 1H NMR和MS波谱数据进行了结构表征. 所得化合物均具有抑制A549肺癌细胞生长的活性, 其抑制效果具有浓度依赖性.

关键词: 2-芳氧甲基环氧烷, 生长抑制活性, α-芳甲基丙二酸二乙酯, 3-芳甲基-5-芳氧甲基丁内酯, A549肺癌细胞

A series of novel 3-arylmethyl-5-aroxymethylbutyrolactone derivatives were synthesized by the reaction of 2-aroxymethyloxirane derivatives with sodium diethyl α-arylmethylmalonates in yields of 13%～81%. These compounds were assayed for inhibitory activity against A549 lung cancer cell growth, and the inhibitory effects on the cell viability were dose-dependent.

Key words: diethyl α-arylmethylmalonate derivative, 2-aroxymethyloxirane derivative, 3-arylmethyl-5-aroxymethylbutyrolactone, growth inhibitory activity, A549 lung cancer cell