有机化学 ›› 2006, Vol. 26 ›› Issue (07): 885-898.    下一篇

综述与进展

固载化试剂和催化剂及其在液相组合合成中的应用

张亮,刘刚*   

  1. (中国医学科学院中国协和医科大学药物研究所 北京 100050)
  • 收稿日期:2005-06-01 修回日期:2005-11-05 发布日期:2006-07-01
  • 通讯作者: 刘刚

Solid-Supported Reagents, Catalysts and Their Use toSolution Phase Synthesis

ZHANG Liang,LIU Gang*   

  1. (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050)
  • Received:2005-06-01 Revised:2005-11-05 Published:2006-07-01
  • Contact: LIU Gang

固载化试剂、催化剂及清洁树脂在液相合成中的应用, 极大地方便了液相合成的后处理, 提高了工作效率, 为液相平行组合合成提供了基础. 重点综述了近年来固载化试剂和催化剂在液相组合合成及多步液相合成中应用进展情况.

关键词: 固载化试剂, 固载化催化剂, 液相合成, 组合合成

The parallel combinatorial solution phase synthesis was already greatly benefited from using solid-supported reagents, catalysts and scavengers in the past decade. Solidified reagents or catalysts could integrate the advantages of the solution phase synthesis and the convenience of the product isolation and purification of solid phase synthesis. This paper reviews the achievement in the single-step, multi-step combinatorial solution-phase synthesis using the solid-supported reagents and catalysts.

Key words: combinatorial synthesis, solid-supported catalyst, solution-phase synthesis, solid-supported reagent