KF-蒙脱土催化下2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃的合成

摘要/Abstract

以KF-蒙脱土为催化剂, 取代肉桂腈与5,5-二甲基-1,3-环己二酮在95%乙醇中回流反应得2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃, 此方法快速、方便、高效, 同时考察了溶剂、催化剂对反应的影响.

关键词: KF-蒙脱土, 肉桂腈, 5,5-二甲基-1,3-环己二酮, 四氢苯并[b]吡喃

The reaction of substituted cinnamonitriles with 5,5-dimethyl-1,3-cyclohexanedione in 95% ethanol catalyzed by KF-montmorillonite, provides a fast, efficient and high-yielding access to 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]pyran. The sig-nificant effects of the solvent and the dosage of catalyst are also discussed.

Key words: cinnamonitrile, KF-montmorillonite, 5,5-dimethyl-1,3-cyclohexanedione, tetrahydrobenzo[b]- pyran

引用此文

庄启亚,吴楠,史达清,屠树江,王香善. KF-蒙脱土催化下2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃的合成[J]. 有机化学, 2006, 26(9): 1217-1220.

ZHUANG Qi-Ya,b,WU Nan^a,SHI Da-Qing*^,a,b
TU Shu-Jiang,b,WANG Xiang-Shan,b. Synthesis of 2-Amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8- tet-rahydrobenzo[b]pyran Catalyzed by KF-Montmorillonite[J]. Chin. J. Org. Chem., 2006, 26(9): 1217-1220.

导出引用 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	刘刚,章荣立,. 聚-ω-(甲硒基)十一烷基硅氧烷钯(0)配合物的合成与催化性能[J]. 有机化学, 2006, 26(02): 215-218.
[2]	史达清,张姝,庄启亚,屠树江,胡宏纹. 水溶剂中取代肉桂腈与β-萘酚的反应[J]. 有机化学, 2003, 23(8): 809-812.
[3]	史达清,张姝,庄启亚,屠树江,胡宏纹. 水中2-氨基-3-氰基-4-芳基-7，7-二甲基-5-氧代4H-5，6，7，8-四氢苯并[b]吡喃的洁净合成[J]. 有机化学, 2003, 23(8): 877-879.