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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (07): 1138-1144. 上一篇    下一篇

综述与进展

Ni(II)螯合物在氨基酸合成中的应用

王江a;邓光辉a;柳红*a;蒋华良a,b

  

  1. a中国科学院上海药物研究所新药研究国家重点实验室药物设计和发现中心 上海 201203
    b华东理工大学药学院 上海 200237
  • 收稿日期:2007-08-17 修回日期:2007-12-12 发布日期:2008-07-28
  • 通讯作者: 柳红

Application of Ni(II) Chelate to Amino Acid Synthesis

WANG, Jianga;DENG, Guang-Huia;LIU, Hong*,a;JIANG, Hua-Lianga,b   

  1. a Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai
    Institute of Materia Medica,
    Chinese Academy of Sciences, Shanghai 20120

    b School of Pharmacy, East China University of Science and Technology, Shanghai 200237

  • Received:2007-08-17 Revised:2007-12-12 Published:2008-07-28
  • Contact: Liu Hong

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668

被引次数

7

Ni(II)螯合物诱导合成氨基酸是氨基酸合成方法中一类新颖且有工业生产价值的合成方法. 从合成方法学
、络合金属离子的优选、配体的改进、卤代片段的选择、合成氨基酸种类等方面介绍该合成方法的研究进
展.

关键词: Ni(II)螯合物, 氨基酸合成, 不对称合成

Synthesis of amino acids via Ni(II) chelate plays an important role in amino acid
preparations. This article reviews the recent progress of this methodology, metal ion
selection, chiral ligand improvement, halide optimization and various kinds of non-natural
amino acid preparation in detail.

Key words: amino acid synthesis, asymmetric synthesis, Ni(II) chelate