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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (2): 288-292. 上一篇    下一篇

研究简报

以2-氨基-2'-羟基-1,1'-联萘为骨架的有机小分子催化的直接羟醛缩合反应的研究

蒋毅*,a,b,c，张小霞a，王超a,c，张国林b，李伯刚b   

  1. (a中国科学院成都有机化学研究所 成都 610041)
    (b中国科学院成都生物研究所 成都 610041)
    (c中国科学院研究生院 北京 100039)
  • 收稿日期:2007-01-17 修回日期:2007-04-14 发布日期:2008-02-01
  • 通讯作者: 蒋毅

Direct Aldol Reactions Catalyzed by Organocatalyst Derived from 2-Amino-2'-hydroxy-1,1'-binaphthyl

JIANG Yi*,a,b,c,ZHANG Xiao-Xiaa,WANG Chaoa,c,ZHANG Guo-Linb,LI Bo-Gangb   

  1. (a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041)
    (b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041)
    (c Graduate School of the Chinese Academy of Sciences, Beijing 100039)
  • Received:2007-01-17 Revised:2007-04-14 Published:2008-02-01
  • Contact: JIANG Yi

PDF

841

被引次数

6

研究了2-氨基-2'-羟基-1,1'-联萘衍生的有机小分子催化剂催化的直接羟醛缩合反应. 以丙酮为反应物时最好, 得到了99%的收率. 以环酮为底物时, 最高得到99∶1的非对映选择性, 89%的对映选择性.

关键词: 2-氨基-2'-羟基-1,1'-联萘, 有机小分子催化剂, 直接羟醛缩合

The direct aldol reactions catalyzed by organocatalyst derived from 2-amino-2'-hydroxy-1,1'- binaphthyl were studied. Up to 99% yield was obtained for acetone. Up to 99∶1 anti∶syn selectivity and 89% enantioselectivity were obtained for cycloalkanones.

Key words: organocatalyst, 2-amino-2'-hydroxy-1,1'-binaphthyl, direct adol reaction