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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (01): 66-70. 上一篇    下一篇

研究论文

新型脂肪族酯和磷酸酯共聚物的合成与表征

张世平; 宫 铭; 马佳妮 ; 韩 琳; 宫永宽*   

  1. (西北大学化学系 合成与天然功能分子化学教育部重点实验室 西安 710069)
  • 收稿日期:2007-12-14 修回日期:2008-07-10 发布日期:2009-01-20
  • 通讯作者: 宫永宽

Synthesis and Characterization of Novel Copolymers of Aliphatics Polyester and Polyphosphoester

Zhang, Shiping; Gong, Ming; Ma, Jiani; Han, Lin; Gong, Yongkuan*   

  1. (Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, Ministry of Education,
    Department of Chemistry, Northwest University, Xi’an 710069)
  • Received:2007-12-14 Revised:2008-07-10 Published:2009-01-20
  • Contact: Gong, Yongkuan

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为了优化脂肪族聚酯和聚磷酸酯在药物控释及基因治疗领域的性能, 以己二酰氯、二氯磷酸乙酯和二缩三乙二醇为原料, 用共缩聚的方法合成了一类新型脂肪族酯和磷酸酯的共聚物. 运用1H NMR, IR对共聚物的结构进行了表征; 利用MALDI-TOF MS测定了共聚物的分子量; 研究了反应时间、投料顺序、溶剂、反应温度和缚酸剂对聚合反应的影响; 通过动态接触角的测定, 探讨了此类聚合物的亲疏水性能; 以中性红为模型药物, 研究了该类聚合物的药物缓释性能.

关键词: 脂肪族聚酯, 聚磷酸酯, 药物缓释, 动态接触角, 中性红

To optimize the biomedical application of aliphatic polyester and polyphosphoester, a series of copolymers containing aliphatic polyester and polyphosphoester segments in the repeat units were synthesized via con-densation polymerization reaction with adipoyl chloride, ethyl dicholorophosphate and triethylene glycol as the beginning materials. The effects of reaction conditions on polymerization were studied and the structures of final polymers were characterized by 1H NMR, FT-IR and MALDI-TOF MS. Dynamic contact angle was used to characterize the surface capability of the polymers. The controlled release character of the copolymers was studied by a fluorescence method using neutral red as a model drug.

Key words: polyphosphoester, aliphatic polyester, dynamic contact angle, drug release, neutral red