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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (03): 396-402. 上一篇    下一篇

研究论文

胆汁酸衍生物三羰基铼核配合物的合成与表征

黄立梁a,b ; 朱 华a,b; 刘贵锋a,b; 许 嘉a ; 沈玉梅*,a   

  1. (a中国科学院上海应用物理研究所 放射性药物研究中心 上海 201800)
    (b中国科学院研究生院 北京 100049)
  • 收稿日期:2008-07-17 修回日期:2008-09-16 发布日期:2009-03-20
  • 通讯作者: 沈玉梅

Synthesis and Characterization of Rhenium Tricarbonyl Core Complexes of Bile Acid Derivatives

Huang, Liliang a,b; Zhu, Hua a,b; Liu, Guifeng a,b; Xu, Jia a; Shen, Yumei *,a   

  1. (a Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics,
    Chinese Academy of Sciences, Shanghai 201800)
    (b Graduate School of the Chinese Academy of Sciences, Beijing 100049)
  • Received:2008-07-17 Revised:2008-09-16 Published:2009-03-20
  • Contact: Shen, Yumei

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以胆酸、鹅去氧胆酸为起始原料, 经羧基的酯化、酯的胺解以及氨基的烷基化, 合成了一系列潜在的针对肝胆显像和肠显像的SPECT (Single photon emission computed tomography)分子探针前体. 该方法简便易行, 合成路线短, 产率高, 它们的结构已经过IR, 1H NMR, 13C NMR, HRMS和元素分析得到了证实. 这些结果为基于以胆汁酸为原料的放射性药物的研究奠定了基础.

关键词: 胆酸, 鹅去氧胆酸, 三齿吡啶配体, 三羰基铼

A series of novel bile acid derivatives as potential hepato-biliary and intestinal scintigraphy imaging SPECT (single photon emission computed tomography) tracers were prepared from bile acids by es-terification, aminolysis of esters and alkylation of amino groups. The procedure is simple and easy to be car-ried out with high yields. Their structures have been confirmed by IR, 1H NMR, 13C NMR, HRMS tech-niques and elemental analysis. These results provide some opportunities for further research on radiophar-maceuticals based on bile acids.

Key words: chenodeoxycholic acid, tridentate pyridine ligand, rhenium tricarbonyl, bile acid