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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (04): 629-633. 上一篇    下一篇

研究简报

手性膦基二茂铁基噁唑啉铱配合物对乙酸肉桂酯衍生物的不对称氢化

孟祥燕; 李新生*; 徐东成   

  1. (a浙江师范大学化学系 金华 321004)
    (b浙江师范大学物理化学研究所 浙江省固体表面反应化学重点实验室 金华 321004)
  • 收稿日期:2008-12-05 修回日期:2008-09-23 发布日期:2009-04-20
  • 通讯作者: 李新生

Asymmetric Hydrogenation of Cinnamyl Acetate Derivatives with Chiral Iridium Ferrocenyloxazolinylphosphine Complexes

Meng, Xiangyan ; Li, Xinsheng*; Xu, Dongcheng   

  1. (a Department of Chemistry, Zhejiang Normal University, Jinhua 321004)
    (b Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry,
    Zhejiang Normal University, Jinhua 321004)
  • Received:2008-12-05 Revised:2008-09-23 Published:2009-04-20
  • Contact: Li, Xinsheng

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被引次数

3

以Fc-PHOX, [Ir(cod)Cl]2和NaBArF为原料高产率地合成了一系列手性Ir-Fc-PHOX配合物, 将其应用于乙酸肉桂酯衍生物的不对称氢化反应, 它们被证明是高效的催化剂, 可以得到完全的转化率和优良的对映选择性, 对映体过量高达99.5% ee.

关键词: 不对称氢化, 烯烃, 铱, 平面手性, 催化剂

A series of chiral iridium Fc-PHOX complexes were readily prepared from Fc-PHOX, [Ir(COD)Cl]2 and NaBArF in high yields, which were proved to be highly efficient catalysts for the enantioselective hydrogenation of (E)-2-methyl-3-phenylallyl acetate derivatives to afford the corresponding products with complete conversions and excellent enantioselectivities (up to 99.5% ee).

Key words: asymmetric hydrogenation, iridium, catalyst, olefin, planar chirality