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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (04): 648-652. 上一篇    下一篇

研究简报

外消旋2-氨基-1-(2,2-二甲基-4H-1,3-苯并二氧芑-6-基)乙醇的拆分研究

全 旭 ; 林成刚 ; 徐 娟; 史海健*   

  1. (南京工业大学化学化工学院 南京 210009)
  • 收稿日期:2008-07-04 修回日期:1900-01-01 发布日期:2009-04-20
  • 通讯作者: 史海健

Resolution of Racemic 6-(2-Amino-1-hydroxyethyl)-2,2-dimethyl- 1,3-benzodioxine

Quan, Xu; Lin, Chenggang; Xu, Juan ; Shi, Haijian*   

  1. (College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009)
  • Received:2008-07-04 Revised:1900-01-01 Published:2009-04-20
  • Contact: Shi, Haijian

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以L-二对甲苯甲酰基酒石酸为拆分试剂, 通过化学拆分法得到了旋光异构体(R)-2-氨基-1-(2,2-二甲基-4H-1,3-苯并二氧芑-6-基)乙醇, 产率高且光学纯度大于98% ee.

关键词: 化学拆分, L-酒石酸衍生物, 氨基乙醇类化合物

An efficient preparation of (R)-6-(2-amino-1-hydroxyethyl)-2,2-dimethyl-1,3-benzodioxine by a chemical resolution in the presence of (－)-di(p-toluoyl)-L-tartaric acid was described. The yield of resolution is high, with the enantiomeric excess being more than 98%.

Key words: L-tartaric acid derivative, chemical resolution, aminoethanol