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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (07): 1068-1081. 上一篇    下一篇

综述与进展

3-哌啶甲酸及其衍生物的合成与应用研究进展

李运波 ; 唐凤翔*; 孟 春; 郭养浩   

  1. (福州大学药物生物技术与工程研究所 福州 350108)
  • 收稿日期:2008-06-21 修回日期:2008-10-25 发布日期:2009-07-22
  • 通讯作者: 唐凤翔

Progress in the Synthesis and Application of Nipecotic Acid and Its Derivatives

Li, Yunbo ; Tang, Fengxiang*; Meng, Chun; Guo, Yanghao   

  1. (Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University, Fuzhou 350108)
  • Received:2008-06-21 Revised:2008-10-25 Published:2009-07-22
  • Contact: Tang, Fengxiang

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4832

被引次数

19 | 3

3-哌啶甲酸及其衍生物是重要的药物中间体, 具有很高的生物活性. 综述了3-哌啶甲酸及其羧基酯化、不饱和、不同位置取代与多取代衍生物的合成方法, 并对3-哌啶甲酸及其衍生物在合成γ-氨基丁酸(GABA)摄入抑制剂、抗肿瘤药、生长激素促分泌素、消炎药物、心血管药物、促智药物、抗流感病毒、骨疾病等药物中的应用进行了概述.

关键词: 3-哌啶甲酸, 3-哌啶甲酸衍生物, 药物中间体

Nipecotic acid and its derivatives, which have high bioactivity, are significant pharmaceutical intermediates. In this review, the synthetic methods of nipecotic acid and its derivatives are summarized. The application of nipecotic acid and its derivatives to synthesizing drugs for γ-aminobutyric acid (GABA) uptake inhibition, cancer chemotherapy, growth hormone secretion, anti-inflammation, cardiovascular disease Alzheimer’s disease, nootropics, anti-flu virus and bone disease is presented as well.

Key words: nipecotic acid derivative, pharmaceutical intermediate, nipecotic acid