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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (11): 1689-1699.    下一篇

综述与进展

糖芯片的研究进展

邹 兰a,b  黄志纾a   黄国贤*,b   古练权*,a   

  1. (a中山大学药学院 广州 510275) (b香港理工大学应用生物与化学技术学系 香港)
  • 收稿日期:2008-10-24 修回日期:2009-02-26 发布日期:2009-04-10
  • 通讯作者: 古练权 E-mail:cesglq@zsulink.zsu.edu.cn

The Research Progress of Carbohydrate Chips

Zou, Lan a,b   Huang, Zhishua   Wong, Kwok Yin*,b   Gu, Lianquan*,a   

  1. (a School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080) (b Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong)
  • Received:2008-10-24 Revised:2009-02-26 Published:2009-04-10

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2130

被引次数

7

糖芯片是生物芯片的一种，如基因芯片对于基因研究和蛋白质芯片对于蛋白质组研究一样，糖芯片在糖组学的研究中同样也将扮演重要的角色。本文系统介绍了糖芯片的制备流程及其应用，以及在糖芯片研发开发中的技术障碍。

关键词: 糖芯片, 微阵列, 生物芯片, 非共价固定, 共价固定

Different techniques for fabrication of carbohydrate chips and their research progress are reviewed. The non-covalent immobilization and covalent immobilization methods of carbohydrates on surfaces are the two major fabrication approaches of carbohydrate chips. However, the strategy that carbohydrates are directly attached onto a surface without modification will be the direction of fabrication of carbohydrate chips. The applications of carbohydrate chips are also discussed.

Key words: carbohydrate chip, microarray, biochip, non-covalent immobilization, covalent immobilization