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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (10): 1165-1168. 上一篇    下一篇

研究论文

N-5-(1H-1,2,4-三唑基）-N'-芳甲酰基脲的合成与生物活性

汪焱钢;赵新筠;龚银香;叶文法;张正文   

  1. 华中师范大学化学学院
  • 发布日期:2003-10-25

Synthesis and Biological Activity of N-5-(1H-1,2,4-Triazolyl)-N'- arylformyl Urea

Wang Yangang;Zhao Xinyun;Gong Yinxiang;Ye Wenfa;Zhang Zhengwen   

  1. College of Chemistry, Central China Normal University
  • Published:2003-10-25

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以5-氨基-1H-1，2，4-三唑-3-羧酸与酰基异氰酸酯反应，合成了15个新的N- 5-（1H-1，2，4-三唑基）-N'-芳甲酰基脲，用核磁共振氢谱、红外光谱和元素分 析确证了其结构，并进行了室内生物活性测试。生测试验证明部分酰基脲类化合物 具有良好的植物生长调节活性，其中N-5（3-羧基-1，2，4-三唑基）-N'-o-氯苯甲 酰基脲、N-5-（3-羧基-1，2，4-三唑基）-N'-o-溴苯甲酰基脲和N-5-(3-羧基-1， 2，4-三唑基）-N'-p(或m)-甲基苯甲酰基脲具有优良的生长素活性。

关键词: 脲;三唑 P;生物活性;生长素;异氰酸酯 P;质子磁共振谱法, 红外分光光度法;元素分析;植物生长调节剂

Fifteen new N-5-(1H-1,2,4-triazolyl)-N'-arylformyl ureas have been synthesized by the reaction of 5-amino-1H-1,2,4-triazol-3-carboxylic acid with arylacyl isocyanate. Their structures were determined by ~1H NMR, IR spectra and elemental analysis. The biological activity tests show that some target compounds have a good activity as plant growth regulator, and N-5-(3-carboxy-1H-1,2,4-triazolyl)-N'-o- chlorophenylfonnyl urea, N-5-(3-carboxy-1H-1,2,4-triazolyl)-N'-o- bromophenylformyl urea, N-5-(3-carboxy-1H-1,2,4-triazolyl)-N'-p-(or m-) methyl-phenyl formyl urea have excellent activity of auxin.

Key words: UREA;PYRRODIAZOLE P;BIOLOGICAL ACTIVITY;AUXIN;ISOCYANIC ESTERS P, 1HNMR;;ELEMENTAL ANALYSIS;PLANT GROWTH REGULATORS

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