有机化学 ›› 2003, Vol. 23 ›› Issue (7): 714-716. 上一篇    下一篇

研究论文

4-N-茄呢基氨基苯甲酸糖酯的合成

赵瑾;宋金勇;王超杰   

  1. 河南大学
  • 发布日期:2003-07-25

Synthesis of 4-N-Solanesylamino-benzoic Acid Glycosyl Esters

Zhao Jin;Song Jinyong;Wang Chaojie   

  1. Key Laboratory of Special Functional Materials, Henan University
  • Published:2003-07-25

在氢氧化钠和四丁基溴化铵存在下,将化合物4-N-茄呢基氨基苯甲酸(3) 分别与O-乙酰基溴代葡萄糖、O-乙酰基溴代半乳糖、O-乙酰基溴代乳糖和O-乙 酰基溴代麦牙糖反应制得对应的糖酯4a-4d,由元素分析,IR,~1H NMR,~(13)C NMR和MS确证了四个新化合物的结构,并做了几种抗癌生理活性测试。

关键词: 茄呢醇;氢氧化钠;四丁基溴化铵;苯甲酸 P;葡萄糖;半乳糖, 元素分析;质子磁共振谱法;碳十三核磁共振谱法;质谱法;抗癌药

Four glycosyl esters were synthesized by the reaction of 4-Ar- solanesylamino-benzoic acid (3) with 0-acetylglucopyranosyl bromide, 0- acetylgalacopyranosyl bromide, O-acetyUactosyl bromide and O-acetyl- maltobiosyl bromide in the presence of ButNBr, respectively. Their structures weve confirmed by IR, 'H NMR, 13C NMR, MS and elemental analysis. The results of anticancer were not satisfactory.

Key words: solanesol;SODIUM HYDROXIDE;ButNBr;BENZENECARBOXYLIC ACID P;GLUCOSE, GALACTOSE;ELEMENTAL ANALYSIS;1HNMR;C13NMR;MS;ANTICARCINOGEN

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