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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (8): 799-803. 上一篇    下一篇

研究论文

双分子维生素B_(12)模型分子的合成及表征

冯亚青;张晓东;孟舒献;张卫红   

  1. 天津大学化工学院精细化工系
  • 发布日期:2003-08-25

Synthesis and Characterization of Dimer-VB_(12) Model Molecules

Feng Yaqing;Zhang Xiaodong;Meng Shuxian;Zhang Weihong   

  1. Department of Fine Chemicals, School of Chemical Engineering and Technology; State Key Laboratory for Cl Chemical Technology, Tianjing University
  • Published:2003-08-25

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被引次数

1

维生素B_(12)经醇解得到的七甲基钴啉酯1作为起始原料，经酸性水解分别得 到b,c,d,e,f-单酸钴啉酯2b～2f, 2b～2f与3-咪唑基丙胺盐酸盐反应合成了相应的 酰胺钴啉酯衍生物3b～3f, 3b～3f在乙酸的作用下合成了双分子络合维生素B_(12) 模型化合物双-单腈六甲基-N-（3-咪唑基）丙酰胺钴啉酯高氯酸盐5b～5f，并对其 化学结构进行了表征。

关键词: 维生素B12, 醇解, 丙酰胺 P, 钴化合物, 结构表征, 高氯酸盐

The starting compound hexamethylcobyrinate (1) obtained by alcoholysis of vitamin B12 was hydrolysed in acid media to give b, c, d, e, f-mono acid cobyrinates 2b ~ 2f. 2b ~ 2f reacted with 3- imidazolyl-propylamine hydrochloride to give amido cobyrinate derivatives 3b ~ 3f. Dimer-vitamin Bjj model molecules, dimer-cyano- hexamethyl-Af-(3-imidazolyl)propylamido cobyrinate perchlorates 5b ~ 5f were synthesized from 3b ~ 3f in the presence of acetic acid. The structures of 5b ~ 5f were characterized.

Key words: VB12;ALCOHOLYSIS;PROPANAMIDE P;COBALT COMPOUNDS;STRUCTURE CHARACTERISTICS, PERCHLORATE

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