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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (9): 1004-1007. 上一篇    下一篇

研究论文

色满-4-酮并[2,3-b]喹啉酮衍生物的合成

韩光范;王进军;姜贵吉   

  1. 华东船舶工业学院材料科学与工程学院;烟台大学应用化学系;延边大学化学 系
  • 发布日期:2003-09-25

Synthesis of Chroman-4-ono[2,3-b]quinolinone Derivatives

Han Guangfan;Wang Jinjun;Jiang Guiji   

  1. School of Materials Science and Engineering, East China Shipbuilding Institute;Department of Applied Chemistry, Yantai University;Department of Chemistry, Yanbian University
  • Published:2003-09-25

PDF

762

被引次数

25

以丙酮和适当的芳香醛以及丙二酸二乙酯为原料，合成出未见报道的5-芳基- 1，3-环已二酮作为合成块。利用Friedlaender合成法与2-氨基-3-甲酰基色满-4- 酮缩合，首次完成色满-4-酮并[2,3-b]喹啉酮新四环系化合物的合成。所合成的化 合物均经~1H NMR,~(13)C NMR，IR光谱和元素分析予以证实。化合物2a的结构也从 色谱-质谱联机分析的质谱数据得到进一步确认。化合物的药理学离体实验表明， 化合物2a具有较强的抑制肿瘤细胞生长的活性。

关键词: 喹啉酮 P;环己二酮;抗癌药;质子磁共振谱法;碳十三核磁共振谱法, 红外分光光度法;元素分析;药理

New building block 5-aryl-l, 3-cyclohexanediones were obtained by reaction of acetone with the appropriate aromatic aldehydes, and sequently with diethyl malonate. 5-Aryl-l, 3-cyclohexanedione and 2- amino-3-formyl-4-chromanone were condensed by utilizing Friedlaender synthetic method to obtain the title compounds. Title compounds were a new form of tetracyclic system. The preliminary in vitro pharmacodynamic experiments show that compound 2a possesses a significant inhibition effect on the growth of tumours cell.

Key words: QUINOLINONE P;CYCLOHEXANEDIONE;ANTICARCINOGEN;1HNMR;C13NMR, IR;ELEMENTAL ANALYSIS;PHARMACOLOGY

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