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有机化学 ›› 2007, Vol. 27 ›› Issue (9): 1126-1129. 上一篇    下一篇

研究论文

虾青素的合成

皮士卿a，陈新志*,a，胡四平b，潘亚金b   

  1. (a浙江大学材料与化工学院 杭州 310027)
    (b浙江医药股份有限公司新昌制药厂 新昌 312500)
  • 收稿日期:2006-02-14 修回日期:2006-11-02 发布日期:2007-08-30
  • 通讯作者: 陈新志

Synthesis of Astaxanthin

PI Shi-Qinga,CHEN Xin-Zhi*,a,HU Si-Pingb,PAN Ya-Jinb   

  1. (a College of Materials Science and Chemical Engineering, Zhejiang University, Hangzhou 310027)
    (b Xinchang Pharmaceuticals Factory, Zhejiang Medicine Co., LTD., Xinchang 312500)
  • Received:2006-02-14 Revised:2006-11-02 Published:2007-08-30
  • Contact: CHEN Xin-Zhi

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被引次数

22 | 6

以α-紫罗兰酮为起始原料, 采用2C15＋C10→C40路线合成了虾青素. 并经过选择性环氧化三甲基硅基烯醇醚双键的关键步骤, 设计并完成了关键中间体C15部分——6-羟基-3-(3-羟基-3-甲基-1,4-戊二烯)-2,4,4-三甲基-2-环己烯-1-酮的合成.

关键词: 类胡萝卜素, 2,7-二甲基-2,4,6-辛三烯-1,8-二醛, α-紫罗兰酮, 6-羟基-3-(3-羟基-3-甲基-1,4-戊二烯)-2,4,4-三甲基-2-环己烯-1-酮, 虾青素

Astaxanthin was synthesized from α-ionone via the route of 2C15＋C10→C40. In which the key intermediate of C15 building block, 6-hydroxy-3-(3-hydroxy-3-methyl-1,4-pentadien-1-yl)-2,4,4-trimethyl- 2-cyclohexen-1-one was obtained by selectively epoxidizing the double bond of trimethylsilyl enol ether as a key step.

Key words: α-ionone, astaxanthin, carotenoid, 2,7-dimethyl-2,4,6-octantrien-1,8-dial, 6-hydroxy-3-(3-hydroxy-3-methyl-1,4-pentadien-1-yl)- 2,4,4-trimethyl-2-cyclohexen-1-one