SIOC English
有机化学
高级检索

有机化学 ›› 2009, Vol. 29 ›› Issue (9): 1462-1465. 上一篇    下一篇

研究简报

4-二甲氨基吡啶催化的1,3-二酮与3-丁炔-2-酮的苯环化反应

周庆发a 辛波涛a 陆 涛a 薛 松*,b   

  1. (a中国药科大学有机化学教研室 南京 210009)
    (b天津大学应用化学系 天津 300191)
  • 收稿日期:2009-01-07 修回日期:2009-02-23 发布日期:2009-12-30
  • 通讯作者: 薛 松

4-Dimethylaminopyridine-Catalyzed Benzannulation Reaction of Aromatic 1,3-Diketones with 3-Butyn-2-one

Zhou, Qingfa a Xin, Botao a Lu, Tao a Xue, Song *,b   

  1. (a Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009)
    (b Department of Applied Chemistry, Tianjin University of Technology, Tianjin 300191)
  • Received:2009-01-07 Revised:2009-02-23 Published:2009-12-30
  • Contact: Xue, Song

PDF

1401

在4-二甲氨基吡啶(DMAP)催化下, 1,3-二酮与3-丁炔-2-酮可以区域选择性地合成四取代的苯, 该方法具有反应条件温和和操作简单等优点, 产物的结构通过IR, 1H NMR, 13C NMR, HRMS确证.

关键词: 多取代苯, 4-二甲氨基吡啶, 3-丁炔-2-酮

4-Dimethylaminopyridine-catalyzed benzannulation reaction of aromatic 1,3-diketones with 3-butyn-2-one providing highly substituted benzenes was developed under mild conditions. The structure of product was confirmed on the basis of 1H NMR, 3C NMR and HRMS techniques.

Key words: 4-dimethylaminopyridine, 3-butyn-2-one, highly substituted benzene