有机化学 ›› 1991, Vol. 11 ›› Issue (3): 322-325. 上一篇    下一篇

研究论文

2-氯甲基呋喃与三烷基炔基硼酸盐的反应研究

李南生;陈燕;邓敏智;马益林   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1991-06-25

The study on the reaction of 2-(chloromethyl)furan with lithium trialkylalkynylborates

LI NANSHENG;CHEN YAN;DENG MINZHI;MA YILING   

  • Published:1991-06-25

本文研究了2-氯甲基呋喃与有机硼酸盐的反应。发现2-氯甲基呋喃在合适的条件下可以与三烷基炔基硼酸盐按正常的方式进行反应, 再经过质子解, 得到带有呋喃环的三取代烯烃, 产率较好。

关键词: 红外分光光度法, 锂化合物, 有机硼酸盐, 呋喃 P, 呋喃 P, 烯烃 P, 质子磁共振谱法, 炔烃 P, 氯甲烷 P, 三烷基

The reaction of 2-(chloromethyl)furan with lithium trialkylalkynylborate is studied and the configuration of the major furfurylalkene reaction product is determine to be E-form by using 1H NMR NOE technique. The ratio of E and Z isomers of the products is about 80:20. Thus, the reaction with high stereoselectivity may be useful for the preparation of furan derivatives

Key words: FURAN P, INFRARED SPECTROPHOTOMETRY, FURAN P, LITHIUM COMPOUNDS, ORGANIC BORATE, ALKENE P, CHLOROMETHANE P, PROTON MAGNETIC RESONANCE SPECTROMETRY, ALKYNE P, TRIALKYL GROUP

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