有机化学 ›› 2008, Vol. 28 ›› Issue (04): 549-573.    下一篇

综述与进展

环肽的合成研究进展

王德心*,韩香,龚喜,冯鹤鹤   

  1. (中国医学科学院中国协和医科大学药物研究所 北京 100050)
  • 收稿日期:2007-01-27 修回日期:2007-06-15 发布日期:2008-04-17
  • 通讯作者: 王德心

Progress in Synthesis of Cyclopeptides

WANG De-Xin*,HAN Xiang,GONG Xi,FENG He-He   

  1. (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050)
  • Received:2007-01-27 Revised:2007-06-15 Published:2008-04-17
  • Contact: WANG De-Xin

对环肽进行了分类, 并对具代表性的经典型、DKP (Diketopiperazine, 哌嗪二酮)型、醚桥型、烯桥型、单硫及多硫醚型、刚性桥型、仲(叔)胺型、Mannich碱型、联苯型及Freidinger型环肽的合成方法逐一进行了描述.

关键词: 环肽分类, 肽结构改造, 环肽合成

Cyclopeptide classifications have been performed systematically in present review, where the synthetic methodologies of the most representative cyclopeptides in documents, such as classical cyclopeptides and atypical cyclopeptides like DKPs (diketopiperazines), Freidingers and some loop chains containing ether, alkene, single or poly sulphur ether, rigid bridge, amine, Mannich base, biphenyl, etc., were described respectively.

Key words: structure modification of peptide, cyclopeptide classification, cyclopeptide synthesis