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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (04): 632-637. 上一篇    下一篇

研究论文

2-胺基(芳氧基)-5,8,9-三甲基噻吩并吡啶并[4,3-d]嘧啶-4(3H)-酮的合成和生物活性

刘建超*,a,b，贺红武*,a，丁明武a   

  1. (a华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079)
    (b中南大学化学化工学院 长沙 410083)
  • 收稿日期:2007-08-01 修回日期:2007-09-12 发布日期:2008-04-17
  • 通讯作者: 贺红武

Synthesis and Biological Activities of 2-(Amino/aroxy)-5,8,9-trimethylthieno[3',2'∶5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives

LIU Jian-Chao*,a,b,HE Hong-Wu*,a,DING Ming-Wua   

  1. (a Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemis-try,
    Central China Normal University, Wuhan 430079)
    (b College of Chemistry and Chemical Engineering, Central South University, Changsha 410083)
  • Received:2007-08-01 Revised:2007-09-12 Published:2008-04-17
  • Contact: HE Hong-Wu*<

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利用串联Aza-Wittig法合成了两类共计16个未见文献报道的噻吩并吡啶并嘧啶类化合物, 通过IR, 1H NMR, EI-MS, 元素分析等方法对所合成的化合物进行了结构表征, 化合物II-1还通过了X单晶衍射的进一步确证. 并初步测定了所合成化合物的杀虫、杀菌和除草活性. 结果表明: 所测化合物的杀虫活性较差, 但大部分化合物具有一定的除草活性和良好的杀菌活性.

关键词: Aza-Wittig法, 吡啶并[4,3-d]嘧啶, 除草活性, 杀菌活性

A series of new 2-(amino/aroxy)-5,8,9-trimethylthieno[3',2'∶5,6]pyrido[4,3-d]pyrimidin- 4(3H)-one derivatives have been designed and synthesized via an aza-Wittig reaction and structually confirmed by elemental analysis, IR, 1H NMR, EI-MS spectra, and compound II-1 by X-ray diffraction analysis. Their biological activities were also researched and many of them showed good fungicidal and herbicidal activities to some extent.

Key words: pyrido[4,3-d]pyrimidine, aza-Wittig reaction, fungicidal activity, herbicidal activity