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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (04): 644-648. 上一篇    下一篇

研究论文

2-乙烯基噻吩-8-羟基喹啉锌的设计合成及光致发光特性研究

刘坚a，曾和平*,a,b，徐丹凤a，魏杰平a   

  1. (a华南师范大学有机化学研究所 广州 510631)
    (b华南理工大学化学科学学院功能分子研究所 广州 510641)
  • 收稿日期:2007-04-25 修回日期:2007-09-14 发布日期:2008-04-17
  • 通讯作者: 曾和平

Synthesis and optical properties of zinc complexes with 2-(2-α-thienylvinyl)-8-hydroxyquinolines

LIU Jiana,ZENG He-Ping*,a,b,XU Dan-Fenga,WEI Jie-Pinga   

  1. (a Department of Chemistry, South China Normal University, Guangzhou 510631)
    (b Institute of Functional Molecules, Faculty of Chemistry, South China University of Technology, Guangzhou 510641)
  • Received:2007-04-25 Revised:2007-09-14 Published:2008-04-17
  • Contact: ZENG He-Ping

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1040

被引次数

11

合成了2-[2-(5-溴代噻吩-2-基)-乙烯基]-8-羟基喹啉(1)和2-[2-(5'-溴代二噻吩-5-基)-乙烯基]-8-羟基喹啉(2)两个新化合物; 利用IR, UV, 1H NMR, MS, 元素分析等确认其结构; 利用X射线单晶衍射仪测定了化合物1的晶体结构; 用MTT法评价了化合物1和2对鼠骨髓间质干细胞在不同浓度下的影响, 研究结果表明它们对鼠骨髓间质干细胞具有增殖作用. 化合物1和2与醋酸锌反应获得了其相应的锌配合物3和4, 光致发光显示: 它们的λmax分别是597和620 nm.

关键词: 2-乙烯基噻吩-8-羟基喹啉, 光致发光, 调控骨髓间质干细胞增殖作用

2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-8-hydroxyquinoline (1) and 2-[2-(5'-bromo-bithiophenyl- 5-yl)-vinyl]-8- hydroxyquinoline (2) were synthesized and characterized by IR, UV, 1H NMR, MS spectra and elemental analysis. The crystal structure of compound 1 was determined by X-ray single crystal diffraction. Their effects on the proliferation of the rat marrow-derived mesenchymal stem cells (rMSC) have been evaluated by an MTT assay. The result of experiment indicated that compounds 1 and 2 could induce the proliferation of mesenchy-mal stem cells (MSC). The compounds 1 and 2 reacted with a Zn(II) salt to afford the cor-responding Zn(II) complexes 3 and 4, and their photoluminescences were showed at λmax 597 and 620 nm respectively.

Key words: photoluminescence, 2-(2-α-thienylvinyl)-8-hydroxyquinoline, regulation of the proliferation of rMSC