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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (12): 1686-1691. 上一篇    下一篇

研究简报

哒嗪并[3,2-c]1,2,4-三唑类化合物的合成

曹玲华*,a,b，王彩芳a，陶晶a   

  1. (a新疆大学化学化工学院 乌鲁木齐 830046)
    (b南开大学元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2006-01-05 修回日期:2006-05-22 发布日期:2006-11-21
  • 通讯作者: 曹玲华

Synthesis of Pyridazino[3,2-c]1,2,4-triazoles

CAO Ling-Hua*,a,b,WANG Cai-Fanga,TAO Jinga   

  1. (a College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046)
    (b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071)
  • Received:2006-01-05 Revised:2006-05-22 Published:2006-11-21
  • Contact: CAO Ling-Hua

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以取代苯和丁二酸酐为起始原料, 经Friedel-Crafts反应, 肼合环, Br2/HOAc氧化脱氢后得到一系列1,6-二氢-3-芳基-6-哒嗪酮(2a～2d). 然后将2a～2d与PCl5在POCl3中回流, 得到相应的氯代产物3a～3d, 将其与酰肼作用, 合环后得到一系列未见报道的哒嗪并[3,2-c]1,2,4-三唑类化合物. 所有化合物结构均经元素分析, IR, 1H NMR 和MS谱得以证实, 并对其波谱性质进行了讨论.

关键词: 哒嗪酮, 哒嗪, 1,2,4-三唑

A series of pyridazino[3,2-c]1,2,4-triazoles were synthesized from hydrazides and 3-aryl-6- chloropyridazines (3a～3d), which were obtained from substituted benzene and succinic anhydride by Friedel-Crafts reaction, cyclization with hydrazine hydrate, dehydrogenation and chloro-substitution. Their structures were established by elemental analysis, IR, 1H NMR and MS spectra.

Key words: pyridazine, 1,2,4-triazole, pyridazinone