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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (03): 372-374. 上一篇    下一篇

研究简报

麦斛细胞毒活性成分研究

谭桂山*,1,2，孙丽3，曹建国3，王秀梅2，李福双2，徐康平2
邓银华2，颜冬兰2，章为2，周应军2，李元建2   

  1. (1中南大学湘雅医院 长沙 410008)
    (2中南大学药学院 长沙 410013)
    (3南华大学肿瘤研究所 衡阳 421001)
  • 收稿日期:2005-04-04 修回日期:2005-09-12 发布日期:2006-02-28
  • 通讯作者: 谭桂山

Cytotoxic Constituents from Bulbuphyllum inconsipicum

TAN Gui-Shan*,1,2,SUN Li3,CAO Jian-Guo3,WANG Xiu-Mei2,LI Fu-Shuang2
XU Kang-Ping2,DENG Yin-Hua2,YAN Dong-Lan2,ZHANG Wei2
ZHOU Ying-J   

  1. (1 Xiangya Hospital Affiliated to Central South University, Changsha 410008)
    (2 School of Pharmaceutical Sciences, Central South University, Changsha 410013)
    (3 Cancer Research Institute, Nanhua University, Hengyang 421001)
  • Received:2005-04-04 Revised:2005-09-12 Published:2006-02-28
  • Contact: TAN Gui-Shan

PDF

1801

被引次数

25

利用硅胶、聚酰胺柱层析等分离方法, 从麦斛全草的乙醚萃取物中分离得到4个化合物, 经化学方法和光谱分析(UV, IR, NMR, MS)鉴定为3,4,7-三羟基-2-甲氧基菲(1), 2,5-二羟基-4-甲氧基菲(2), eugenitin (3)和2,5-二羟基-4-甲氧基-9,10-二氢菲(4), 其中1为新化合物. 采用MTT法分别测得化合物1和2对体外培养的人急性髓性白血病细胞和人肝癌细胞增殖的抑制活性, 并分别考察了增敏剂葛根素对化合物1和2增殖活性的协同作用.

关键词: 麦斛, 葛根素, 3,4,7-三羟基-2-甲氧基菲, 人急性髓性白血病细胞, 人肝癌细胞

A novel compound, 2-methoxy-3,4,7-trihydroxy-phenanthrene (1), along with 4-methoxy- 2,5-dihydroxy-phenathrene (2), eugenitin (3) and 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (4), was isolated from Bulbuphyllum inconsipicum. 1 and 2 suppressing HL-60 and SMMC-7721 cells were investigated in vitro with cytotoxic activity. Furthermore, synergistic inhibition of 1 and 2 with pu-erarin was assessed.

Key words: 2-methoxy-3,4,7-trihydroxy-phenanthrene, cytotoxic activity, puerarin, Bulbuphyllum inconsipicum