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有机化学 ›› 2005, Vol. 25 ›› Issue (06): 700-704. 上一篇    下一篇

研究论文

新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物的合成及抗菌活性

惠新平*,1，张艳1，许鹏飞*,1，王勤2，张琪2，张自义1   

  1. (1兰州大学功能有机分子化学国家重点实验室 化学化工学院 兰州 730000)
    (2兰州大学生命科学学院 兰州 730000)
  • 收稿日期:2004-11-09 修回日期:2004-12-27 发布日期:2005-05-30
  • 通讯作者: 许鹏飞

Synthesis and Antibacterial Activities of Novel 4-Substituted-6- (4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-1',2',4'-tri-azolo[3,4-b]- 1",3",4"-thiadiazines

HUI Xin-Ping*1, ZHANG Yan1, XU Peng-Fei*1, WANG Qin2, ZHANG Qi2, ZHANG Zi-Yi1   

  1. (1 State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engi-neering,
    Lanzhou University, Lanzhou 730000)
    (2 College of Life Science, Lanzhou University, Lanzhou 730000)
  • Received:2004-11-09 Revised:2004-12-27 Published:2005-05-30
  • Contact: XU Peng-Fei

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通过3-取代-4-氨基-5-巯基-1,2,4-三唑(3a～3m)和2-溴-2-(1H–1,2,4-三唑-1-基)-4′-氯代苯乙酮(2)的缩合反应, 合成了13个新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物4a～4m. 化合物结构经元素分析, 1H NMR, IR和MS进行了表征. 抗菌试验表明所合成的化合物对细菌表现出中等程度的抑制活性.

关键词: 抗菌活性, 1H-1,2,4-三唑, 1,2,4-三唑[3,4-b]-1',3',4'-噻二嗪

The synthesis of novel 4-substituted-6-(4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-s-triazolo[3,4- b]-1',3',4'-thiadiazines (4a～4m) by the condensation of 4-amino-5-mercapto-3-substituted-1,2,4-triazoles (3a～3m) with 2-bromo-2-(1H-1,2,4-triazol-1-yl)-4′-chloroacetophenone (2) was described. The structures of compounds were confirmed by elemental analyses, IR, 1H NMR and mass spectral data. These compounds have also been screened for their antibacterial activities.

Key words: 1,2,4-triazolo[3,4-b]-1',3',4'-thiadiazine, antibacterial activity, 1H-1,2,4-triazole