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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (12): 1640-1646. 上一篇    下一篇

综述与进展

氮杂唑合成反应在生物缀合物研究中的应用

李研，巨勇*，赵玉芬   

  1. (清华大学化学系 生命有机磷与化学生物学教育部重点实验室 北京 100084)
  • 收稿日期:2005-09-14 修回日期:2006-04-08 发布日期:2006-11-21
  • 通讯作者: 巨勇

Application of Azoles Synthesis in Bioconjugate Chemistry

LI Yan,JU Yong*,ZHAO Yu-Fen   

  1. (Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education,
    Department of Chemistry, Tsinghua University, Beijing 100084)
  • Received:2005-09-14 Revised:2006-04-08 Published:2006-11-21
  • Contact: JU Yong

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1752

被引次数

5 | 2

介绍了利用1,3-偶极环加成反应合成氮杂三唑和氮杂四唑的设计方法和反应特点, 以及氮杂唑类化合物的合成在生物缀合物研究中的应用.

关键词: 生物缀合物, 1,3-偶极环加成反应, 氮杂唑

The characterization of “Click Chemistry” (the 1,3-dipolar cycloaddition combined with the synthetic design of triazoles and tetrazoles) is reviewed, and some recent examples of various bioconjugates synthesis are introduced based on the “Click Chemistry”.

Key words: bioconjugate chemistry, azole, 1,3-dipolar cycloaddition